- Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii
-
Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 μM.
- Nakamura, Fumiaki,Maejima, Hiroshi,Kawamura, Midori,Arai, Daisuke,Okino, Tatsufumi,Zhao, Meng,Ye, Tao,Lee, Jungyeol,Chang, Young-Tae,Fusetani, Nobuhiro,Nakao, Yoichi
-
supporting information
p. 2206 - 2209
(2018/05/25)
-
- Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens
-
A family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A-D (1-4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of dudawalamides A-D were determined by a combination of 1D and 2D NMR experiments and MS analysis, whereas the absolute configurations were determined by X-ray crystallography, modified Marfey's analysis, chiral-phase GCMS, and chiral-phase HPLC. Dudawalamides A-D possess a broad spectrum of antiparasitic activity with minimal mammalian cell cytotoxicity. Comparative analysis of the Dhoya-containing class of lipopeptides reveals intriguing structure-activity relationship features of these NRPS-PKS-derived metabolites and their derivatives.
- Almaliti, Jehad,Malloy, Karla L.,Glukhov, Evgenia,Spadafora, Carmenza,Gutiérrez, Marcelino,Gerwick, William H.
-
p. 1827 - 1836
(2017/06/28)
-
- Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides
-
A new 3-amino-6-hydroxy-2-piperidone (Ahp) containing peptolide, pompanopeptin A (1), and a novel N-methyl-2-amino-6-(4′-hydroxyphenyl)hexanoic acid (N-Me-Ahpha) containing cyclic pentapeptide connected with a sixth amino acid residue via a rare ureido linkage, pompanopeptin B (2), were isolated from the marine cyanobacterium Lyngbya confervoides collected from the southeastern coast of Florida. Their planar structures were determined by a combination of NMR spectroscopic analysis and mass spectrometry. The absolute configurations were established using advanced Marfey's method and chiral HPLC analysis of the chemical degradation products. Compound 1 selectively inhibited trypsin over elastase and chymotrypsin, with an IC50 value of 2.4 μM; selectivity is conferred by an arginine residue in the cyclic core.
- Matthew, Susan,Ross, Cliff,Paul, Valerie J.,Luesch, Hendrik
-
p. 4081 - 4089
(2008/09/20)
-
- MAJUSCULAMIDE D AND DEOXYMAJUSCULAMIDE D, TWO CYTOTOXINS FROM LYNGBYA MAJUSCULA
-
Majusculamide D and deoxymajusculamide D are cytotoxic lipopentapeptides that are minor constituents of a deep-water variety of the marine blue-green alga Lyngbya majuscula from Enewetak. Key Word Index - Lyngbya majuscula; Oscillatoriaceae; blue-green alga; lipopentapeptides; cytotoxins.
- Moore, Richard E.,Entzeroth, Michael
-
p. 3101 - 3104
(2007/10/02)
-
- Studies on the antitumor cyclic hexapeptides obtained from Rubiae radix
-
Antitumor cyclic hexapeptides named RA-VII, V, IV and III were isolated from the MeOH extracts of Rubia cordifolia and R. akane.
- Itokawa,Takeya,Mihara,Mori,Hamanaka,Sonobe,Iitaka
-
p. 1424 - 1427
(2007/10/02)
-
