52939-33-0

Usage

Uses

Used in Pharmaceutical Development:
N-ME-4-METHOXY-PHE-OH is used as a precursor or intermediate in the synthesis of various pharmaceutical drugs and active ingredients. Its unique structure and functional groups contribute to the development of new therapeutic agents with potential applications in treating various medical conditions.
Used in Scientific Research:
In the scientific community, N-ME-4-METHOXY-PHE-OH is utilized for research purposes to explore its properties, potential uses, and mechanisms of action. N-ME-4-METHOXY-PHE-OH serves as a valuable tool for understanding the structure-activity relationships and pharmacological effects of phenethylamine derivatives.

Upstream product

• 112176-77-9 5-(4-methoxy-benzyl)-1,3-dimethyl-imidazolidine-2,4-dione 
• 21405-61-8 2-(4-methoxybenzylidene)malonic acid 
• 21405-62-9 2-(4-methoxybenzyl)malonic acid 
• 122621-60-7 RA-VII 
• 73584-84-6 (S)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-methoxyphenyl)propanoic acid 
• 861545-92-8 bromo-(4-methoxy-benzyl)-malonic acid 

Downstream Products

• 19897-63-3 N-methyltyrosine 
• 1006727-52-1 C₁₁H₁₄BrNO₃ 
• 1357361-40-0 (+)-(S)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-methylaminopropanoate 
• 1357361-44-4 (+)-(S)-3-(3,5-dibromo-4-methoxyphenyl)-2-methylaminopropanoic acid hydrochloride 
• 1357361-52-4 (-)-(S)-3-(3,5-dibromo-4-methoxyphenyl)-2-(N-methyl-2-methylprop-2-yloxycarbamoyl)propanoic acid 
• 99557-34-3 3-hydroxy-4-(4'-methoxyphenyl)-2(1H)-quinolinone 

Relevant academic research and scientific papers

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 μM.

Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens

A family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A-D (1-4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of dudawalamides A-D were determined by a combination of 1D and 2D NMR experiments and MS analysis, whereas the absolute configurations were determined by X-ray crystallography, modified Marfey's analysis, chiral-phase GCMS, and chiral-phase HPLC. Dudawalamides A-D possess a broad spectrum of antiparasitic activity with minimal mammalian cell cytotoxicity. Comparative analysis of the Dhoya-containing class of lipopeptides reveals intriguing structure-activity relationship features of these NRPS-PKS-derived metabolites and their derivatives.

Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides

A new 3-amino-6-hydroxy-2-piperidone (Ahp) containing peptolide, pompanopeptin A (1), and a novel N-methyl-2-amino-6-(4′-hydroxyphenyl)hexanoic acid (N-Me-Ahpha) containing cyclic pentapeptide connected with a sixth amino acid residue via a rare ureido linkage, pompanopeptin B (2), were isolated from the marine cyanobacterium Lyngbya confervoides collected from the southeastern coast of Florida. Their planar structures were determined by a combination of NMR spectroscopic analysis and mass spectrometry. The absolute configurations were established using advanced Marfey's method and chiral HPLC analysis of the chemical degradation products. Compound 1 selectively inhibited trypsin over elastase and chymotrypsin, with an IC50 value of 2.4 μM; selectivity is conferred by an arginine residue in the cyclic core.

MAJUSCULAMIDE D AND DEOXYMAJUSCULAMIDE D, TWO CYTOTOXINS FROM LYNGBYA MAJUSCULA

Majusculamide D and deoxymajusculamide D are cytotoxic lipopentapeptides that are minor constituents of a deep-water variety of the marine blue-green alga Lyngbya majuscula from Enewetak. Key Word Index - Lyngbya majuscula; Oscillatoriaceae; blue-green alga; lipopentapeptides; cytotoxins.

Studies on the antitumor cyclic hexapeptides obtained from Rubiae radix

Antitumor cyclic hexapeptides named RA-VII, V, IV and III were isolated from the MeOH extracts of Rubia cordifolia and R. akane.