- Dihydro benzoxazinones and benzoxazinediones' derivatives : thesis and study as bactericides and fungicides
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A series of 3,4 dihydro 2 H 1,3 benzoxazine 2,4 diones and 3,4 dihydro 2 H 1,3 benzoxazine 4 ones were synthesized from several salicylamides and salicylanilides. Their antibacterial and antifungal activities in vitro were studied on Staphylococcus aureus 209 P A.T.C.C. (6538 P), Pseudomonas aeruginosa I.P. C.C.E.B. 481, Escherichia coli K 12 C600 (λ-) and Candida albicans. Always negative on colibacillus, activity on Staphylococcus aureus seems to be conditioned by presence of halogeno or nitro substituents: one of the compounds is notably active. Transformation into the heterocyclic derivative generally lowers or cancels action on Candida albicans; conversely, it frequently provokes action on Bacillus pyocyaneus on which some monoketonic derivatives were quite effective.
- Devaux,Renaudie,Boineau,et al.
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