53187-58-9

Basic information

• Product Name: hydrocortisone acetate
• Synonyms: [2-[(8S,9S,10R,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
• CAS NO: 53187-58-9
• Molecular Formula: C₂₃H₃₂O₆
• Molecular Weight: 404.50
• Mol File: 53187-58-9.mol

Chemical Properties

• Boiling Point: 576.556 °C at 760 mmHg
• Flash Point: 196.167 °C
• Appearance: /
• Density: 1.267 g/cm³
• CAS DataBase Reference: hydrocortisone acetate(CAS DataBase Reference)
• NIST Chemistry Reference: hydrocortisone acetate(53187-58-9)
• EPA Substance Registry System: hydrocortisone acetate(53187-58-9)

Safety Data

• Hazardous Substances Data: 53187-58-9(Hazardous Substances Data)

Usage

Uses

Used in Dermatological Applications:
Hydrocortisone acetate is used as a topical medication for reducing inflammation and relieving itching, redness, and swelling in various skin conditions such as eczema, psoriasis, allergic reactions, and insect bites. It works by suppressing the body's immune response and decreasing the release of inflammatory substances in the skin.
Used in Pharmaceutical Industry:
Hydrocortisone acetate is used as an active ingredient in various formulations such as creams, lotions, ointments, and gels for the treatment of skin conditions. It is considered a safe and effective option for short-term use, but prolonged use can lead to skin thinning, discoloration, and other side effects. Therefore, it should be used under the guidance of a healthcare professional to ensure optimal therapeutic outcomes and minimize potential adverse effects.

Upstream product

• 50-23-7 cortisol 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Preparation process of hydrocortisone acetate

The invention relates to a preparation process of hydrocortisone acetate. The preparation process comprises the following steps: under the action of 4-dimethylamiopryidine, enabling hydrocortisone and acetic anhydride to directly react, without the need of additionally utilizing a solvent; washing into water and separating out materials; filtering and drying to prepare the hydrocortisone acetate. The technical problem in the prior art that a reaction process commonly needs pyridine or a pyridine substitute solvent is overcome; the large-batch production capability of a reaction kettle is greatly improved and a condition that a lot of industrial wastewater difficult to treat is generated is avoided. The preparation process has a simple process, is good for environment protection, is low in cost and is suitable for industrial large-scale production.