Acticort (Baker Norton); Ala-Cort (Del
Ray); Cetacort (Healthpoint); Colocort (Paddock); Cort-
Dome (Bayer); Cortef (Pharmacia & Upjohn); Cortenema
(Solvay Pharmaceuticals); Cortril (Pfizer); Dermacort
(Monarch); Dermacort (Solvay Pharmaceuticals); Eldecort
(Valeant); Epicort (Bluline); Flexicort (Westwood-
Squibb); Glycort (Heran); Hi-Cor (C & M); Hydro-Rx (X
Gen); Hydrocortone (Merck); Hytone (Dermik); Hytone
(Sanofi Aventis); Nutracort (Healthpoint); Penecort (Allergan);
Proctocort (Monarch); Stie-Cort (Stiefel); Synacort
(Medicis); Texacort (Sirius).
Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.
Hydrocortisone is the principal glucocorticoid hor-
mone produced by the adrenal cortex and is used topi-
cally or systemically. It belongs to the allergenic A
group. Marker of allergy is tixocortol pivalate.
ChEBI: A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex,
which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immun
Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level
of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
crystalline white powder
Recrystallise hydrocortisone from EtOH or isoPrOH. It is bitter tasting and has UV with max at 242 nm (log 4.20). Its solubility at 25o is: H2O (0.28%), EtOH (1.5%), MeOH (0.62%), Me2CO (0.93%), CHCl3 (0.16%), propylene glycol (1.3%) and Et2O (0.35%). It gives an intense green colour with conc H2SO4. [Wendler et al. J Am Chem Soc 72 5793 1950, Beilstein 8 IV 3422.]