- Thermodynamic control of diastereoselectivity in the formal nucleophilic substitution of bromocyclopropanes
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(Figure Presented) A new, general, and chemoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides is described. A wide range of alcohols and phenols can be employed as pronucleophiles in this transformation, providi
- Banning, Joseph E.,Prosser, Anthony R.,Rubin, Michael
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- Synthesis of novel precursors of calicene and 7-methylcalicene
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Cyclopent-2-en-1-one is a versatile electrophilic cyclopentadiene equivalent in reactions with 1-bromo-1-lithiocyclopropanes. The synthetic sequence (outlined in Scheme 1) has been applied to the synthesis of functionalized 7-X-7,8-dihydrocalicenes 13c (Scheme 3) and 13d (Scheme 4). 7- Bromo-7,8-dihydrocalicene (13d) is considered to be a promising precursor of the so far unknown parent calicene (2). A similar sequence has been realized for 7-(chloromethyl)-7,8-dihydrocalicene (21a, Scheme 5) which, under appropriate conditions, could give 7-methylcalicene (16).
- Al-Dulayymi, Ahmad,Li, Xiaoming,Neuenschwander, Markus
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- Unusual selectivity in the oxidative functionalization of gem-dibromocyclopropanes
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Oxidation of gem-dibromocyclopropanes with chromium trioxide in acetic acid or a number of other reagents is generally slower than that of the corresponding cyclopropane; in a number of cases moderate yields of products are obtained but these show unexpected oxidation patterns.
- Nizovtsev, Alexey V.,Baird, Mark S.,Bolesov, Ivan G.
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p. 3717 - 3729
(2007/10/03)
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- 6-(Substituted-cycloalkylcarboxamide) penicillanic acids
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Penicillins of the formula SPC1 Or a pharmaceutically-acceptable, nontoxic salt thereof, Wherein R1 and R2 are the same or different and each is hydrogen, fluorine, chlorine or bromine; or when R2 is hydrogen, R1 can also be cyano, hydroxyl, azido, amino or nitro; or R1 and R2 are bonded to a ring carbon atom and constitute a single oxygen atom; R3 is hydrogen, methyl, chlorine, bromine, cyano, methoxy or carboxyl; and n is 2 to 7; Are useful for their antibacterial activity.
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