- Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases
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A series of chlamydocin analogs with various carbonyl functionalities were designed and synthesized as histone deacetylase (HDAC) inhibitors. Chlamydocin is a cyclic tetrapeptide containing an epoxyketone surrogate in the side chain which makes it irrever
- Bhuiyan, Mohammed P.I.,Kato, Tamaki,Okauchi, Tatsuo,Nishino, Norikazu,Maeda, Satoko,Nishino, Tomonori G.,Yoshida, Minoru
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p. 3438 - 3446
(2007/10/03)
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- A plant growth retardant related to chlamydocin and its proposed mechanism of action
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A comparison of the plant growth retardant activity of the chlamydocin analogues, compound 1, six derivatives from 1 and 2, and two synthetic analogues revealed that there are two types of retardant in chlamydocin analogues. One, for example in compound 1, requires an oxygen atom at C-8 of the 2-aminodecanoic acid moiety to show retardant activity. The other, for example in compound 8, requires no oxygen atom at C-8 but requires a specific alkyl group chain length for activity. To determine the differences in mode of action of both types of retardant, rice seedlings were separately treated with compounds 1 and 8, and after appearance of dwarfism, their endogenous ABA and GA1 levels were determined and compared to those of the control. Treatment with 1 (10 nmol/plant) increased ABA levels 4 times higher than that of the control and decreased GA1 levels to 20% of that of the control. Treatment with 8 (30 nmol/plant) did not affect the ABA level but decreased GA1 content to 5% of that of the control.
- Tani, Hiroko,Honma, Tamaki,Fujii, Yuzo,Yoneyama, Koichi,Nakajima, Hiromitsu
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p. 1133 - 1140
(2007/10/03)
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