- Mononuclear Ni(II) and dinuclear Cd(II) complexes of 4-phenyl-2H-1,2,4- triazole-3-thione and Mn(II) catalyzed disulphide bond formation in 3,3′-dithiobis (4-phenyl-1,2,4-triazole): Syntheses, structural characterization, thermal analysis and DFT calculat
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New complexes [Ni(phtt)2(en)2] (2) and [Cd 2(μ-phtt)2(phtt)2(bpy)2] (3) have been synthesized by the reactions of M(NO3)2· xH2O and 4-phenyl-2H-1,2,4-triazo
- Dani,Bharty,Paswan,Singh, Sanjay,Singh
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- Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives
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Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.
- Kusmierz, Edyta,Siwek, Agata,Kosikowska, Urszula,Malm, Anna,Plech, Tomasz,Wrobel, Andrzej,Wujec, Monika
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p. 1539 - 1545
(2015/10/29)
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- Synthesis and antimicrobial and pharmacological properties of new thiosemicarbazide and 1,2,4-triazole derivatives
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Reaction of 4-phenyl-4H-1,2,4-triazole-3-thione with ethyl bromoacetate has led to the formation of ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 1, the structure of which was confirmed by X-ray analysis. In the next reaction with 80% hydrazide hydrate, appropriate hydrazide 2 was obtained, which in reaction with isothiocyanates was converted to new acyl derivatives of thiosemicarbazides 3a-3h. The cyclization of these compounds in alkaline media has led to formation of new derivatives of 5-{[(4-phenyl-4H-1,2,4-triazole-3-yl) sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thiones 4a-4g, 4j. The structure of the compounds was confirmed by elementary analysis and IR, 1H-NMR, 13C-NMR, and MS spectra. Compounds 3a-3h and 4a-4g were screened for their antimicrobial activities, and the influence of the compounds 4a, 4b, and 4e-4g on the central nervous system of mice in behavioral tests was examined.
- Popiolek, Lukasz,Dobosz, Maria,Chodkowska, Anna,Jagiello-Wojtowicz, Ewa,Kosikowska, Urszula,Malm, Anna,Mazur, Liliana,Rzaczynska, Zofia
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p. 339 - 346
(2011/06/19)
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- Synthesis of amides of 2,4-dioxothiazolidin-5-yl acetic acid with 1,2,4-triazole substituents
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In the reaction of (2,4-dioxothiazolidin-5-yl)acetyl chloride with 1,2,4-triazole, 4-phenyl-1,2,4-triazolin-5-one and 4-phenyl-1,2,4-triazolin-5- thione, the new corresponding amides (2-4) were obtained. For compounds 2 and 4 effects on central nervous system (CNS) of mice were studied.
- Trotsko, Nazar,Dobosz, Maria,Chodkowska, Anna,Jagiello-Wojtowicz, Ewa
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p. 217 - 221
(2009/04/04)
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- The reactions of cyclization of thiosemicarbazide derivatives to 1,2,4-triazole or 1,3,4-thiadiazole system
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In the reaction of hydrazide of formic, nicotinic and benzoic acid with isothiocyanates were obtained the respective thiosemicarbazide derivatives [I-XII]. Further cyclization with 2% NaOH solution led to formation of derivatives Δ2-1,2,4-triaz
- Dobosz, Maria,Pitucha, Monika,Wujec, Monika
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- The Synthesis of 4-Substituted-4H-1,2,4-triazole-3-thiols and 3-Methylthio-4-substituted-4H-1,2,4-triazoles
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The synthesis of 4-substituted-4H-1,2,4-triazole-3-thiols and 3-methylthio-4-substituted-4H-1,2,4-triazoles by the condensation of 4-substituted-3-thiosemicarbazides with dimethylformamide dimethyl acetal or dimethylacetamide dimethyl acetal is described.A discussion of the mechanistic pathway is included.
- Lin, Yang-i,Petty, S. R.,Lowell, F. M.,Perkinson, N. A.,Lang, S. A.
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p. 1077 - 1080
(2007/10/02)
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