5373-72-8

Usage

Uses

Used in Pharmaceutical Industry:
4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL is used as a key intermediate in the synthesis of pharmaceuticals for its antimicrobial, antioxidant, and anticancer properties. Its versatile reactivity allows for the development of new compounds with potential therapeutic applications.
Used in Organic Synthesis:
PTZT is used as a building block in organic synthesis for creating new compounds with potential biological activities. Its unique structure and properties make it a valuable component in the development of novel chemical entities.
Used in Medicinal Chemistry:
4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL is used as a ligand in medicinal chemistry for the synthesis of coordination complexes and metal-organic frameworks. This application contributes to the advancement of drug discovery and the development of new therapeutic agents.
Used in Antimicrobial Applications:
PTZT is employed as an antimicrobial agent, leveraging its ability to combat various microorganisms. Its incorporation into pharmaceuticals and other products can help address the growing concern of antibiotic resistance.
Used in Antioxidant Formulations:
4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL is used in antioxidant formulations to protect against oxidative stress and related cellular damage. Its antioxidant properties make it a promising candidate for use in health and skincare products.
Used in Coordination Complexes and Metal-Organic Frameworks:
PTZT is used as a ligand in the synthesis of coordination complexes and metal-organic frameworks, contributing to the development of new materials with potential applications in catalysis, sensing, and drug delivery.

InChI:InChI=1/C8H7N3S/c12-8-10-9-6-11(8)7-4-2-1-3-5-7/h1-6H,(H,10,12)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 624-84-0 formic acid hydrazide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 3682-28-8 [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetic acid 
• 76457-73-3 3-(methylthio)-4-phenyl-4H-1,2,4-triazole 
• 16227-12-6 1-phenyl-1,3,4-triazole 
• 2160-15-8 2-morpholin-4-ylmethyl-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 18333-83-0 2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-hydroxyphenyl)methylidene]acetohydrazide 
• 18333-84-1 2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[(4-methoxyphenyl)methylidene]acetohydrazide 
• 77934-34-0 Ag⁽¹⁺⁾*C₈H₆N₃S^(1-)=AgC₈H₆N₃S 
• 198063-99-9 4-(4-chlorophenyl)-2-(4-phenyl-4H-1,2,4-triazol-3-ylthio)-5-oxazolepropionic acid 
• 84210-48-0 ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 
• 6264-24-0 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-phenylthiosemicarbazide 
• 59909-04-5 [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide 
• 1306760-99-5 4-carboxymethyl-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-26-8 4-(4-bromophenyl)-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1289425-24-6 4-cyclohexyl-5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 

Relevant academic research and scientific papers

Mononuclear Ni(II) and dinuclear Cd(II) complexes of 4-phenyl-2H-1,2,4- triazole-3-thione and Mn(II) catalyzed disulphide bond formation in 3,3′-dithiobis (4-phenyl-1,2,4-triazole): Syntheses, structural characterization, thermal analysis and DFT calculat

New complexes [Ni(phtt)2(en)2] (2) and [Cd 2(μ-phtt)2(phtt)2(bpy)2] (3) have been synthesized by the reactions of M(NO3)2· xH2O and 4-phenyl-2H-1,2,4-triazo

Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.

Synthesis and antimicrobial and pharmacological properties of new thiosemicarbazide and 1,2,4-triazole derivatives

Reaction of 4-phenyl-4H-1,2,4-triazole-3-thione with ethyl bromoacetate has led to the formation of ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 1, the structure of which was confirmed by X-ray analysis. In the next reaction with 80% hydrazide hydrate, appropriate hydrazide 2 was obtained, which in reaction with isothiocyanates was converted to new acyl derivatives of thiosemicarbazides 3a-3h. The cyclization of these compounds in alkaline media has led to formation of new derivatives of 5-{[(4-phenyl-4H-1,2,4-triazole-3-yl) sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thiones 4a-4g, 4j. The structure of the compounds was confirmed by elementary analysis and IR, 1H-NMR, 13C-NMR, and MS spectra. Compounds 3a-3h and 4a-4g were screened for their antimicrobial activities, and the influence of the compounds 4a, 4b, and 4e-4g on the central nervous system of mice in behavioral tests was examined.

Synthesis of amides of 2,4-dioxothiazolidin-5-yl acetic acid with 1,2,4-triazole substituents

In the reaction of (2,4-dioxothiazolidin-5-yl)acetyl chloride with 1,2,4-triazole, 4-phenyl-1,2,4-triazolin-5-one and 4-phenyl-1,2,4-triazolin-5- thione, the new corresponding amides (2-4) were obtained. For compounds 2 and 4 effects on central nervous system (CNS) of mice were studied.

The reactions of cyclization of thiosemicarbazide derivatives to 1,2,4-triazole or 1,3,4-thiadiazole system

In the reaction of hydrazide of formic, nicotinic and benzoic acid with isothiocyanates were obtained the respective thiosemicarbazide derivatives [I-XII]. Further cyclization with 2% NaOH solution led to formation of derivatives Δ2-1,2,4-triaz

The Synthesis of 4-Substituted-4H-1,2,4-triazole-3-thiols and 3-Methylthio-4-substituted-4H-1,2,4-triazoles

The synthesis of 4-substituted-4H-1,2,4-triazole-3-thiols and 3-methylthio-4-substituted-4H-1,2,4-triazoles by the condensation of 4-substituted-3-thiosemicarbazides with dimethylformamide dimethyl acetal or dimethylacetamide dimethyl acetal is described.A discussion of the mechanistic pathway is included.