- Regioselective synthesis of 1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones: Kinetic studies and selective pyrolytic deprotection
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Selective pyrolytic deprotection of 2-ethyl and 2-cyanoethyl-4-arylidenimino-1,2,4-triazol-3(2H)-ones and their 3(2H)-thiones was studied by flash vacuum pyrolysis. This study is useful in regioselective synthesis of 2-and 4-substituted 1,2,4-triazoles of potential biological applications. The kinetic results and product analysis lend support to a reaction pathway involving a six-membered transition state.
- Al-Awadi, Nouria A.,Ibrahim, Yehia A.,Kaul, Kamini,Dib, Hicham
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- Gas-phase elimination reactions of 4-arylideneimino-2-cyanoethyl-1,2,4-triazol-3(2H)-ones, their thione analogues and 2-glucosyl-1,2,4-triazole-3(2H)-thiones: A kinetic and mechanistic study
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Several 4-arylidenimino-2-cyanoethyl-1,2,4-triazol-3(2H)-ones, their 3(2H)-thiones and 2-glucosyl-1,2,4-triazol-3(2H)-thiones (1-12) were synthesized. Selective pyrolytic deprotection of these derivatives was studied in the gas phase and the kinetics of the reactions were measured for each compound. First-order rate constants measured over a 45 °C temperature range were used to calculate the Arrhenius activation parameters. A comparison of the products and the kinetic behavior of the thermal decomposition of these compounds are discussed. Copyright
- Al-Awadi, Nouria A.,Ibrahim, Yehia A.,Dib, Hicham,Kaul, Kamini
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p. 324 - 329
(2007/10/03)
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