- Synthesis and evaluation of new N6-substituted adenosine-5′-N-methylcarboxamides as A3 adenosine receptor agonists
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A number of N6-substituted adenosine-5′-N-methylcarboxamides were synthesised and their pharmacology, in terms of their receptor affinity, selectivity and cardioprotective effects, were explored. The first series of compounds, 4a-4f and 5a-5f,
- Devine, Shane M.,Gregg, Alison,Figler, Heidi,McIntosh, Kate,Urmaliya, Vijay,Linden, Joel,Pouton, Colin W.,White, Paul J.,Bottle, Steven E.,Scammells, Peter J.
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experimental part
p. 3078 - 3087
(2010/07/08)
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- Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides
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A series of 3,5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2,6-di-tert-butyl-4-methyl phenol groups have submicromolar inhibitory activities.
- Kang, Tae-Souk,Jo, Hyang-Ok,Park, Woo-Kyu,Kim, Jong-Pyung,Konishi, Yasuo,Kong, Jae-Yang,Park, No-Sang,Jung, Young-Sik
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p. 1663 - 1667
(2008/12/21)
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- Synthesis and inhibitory activity of alkyl(hydroxyaryl)amines
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The reaction of ω-(4-hydroxyaryl)haloalkanes with various nitrogen-containing agents afforded primary, secondary, and tertiary amino derivatives of 2,6-dialkylphenols. For the compounds synthesized, the reaction rate constants with peroxide radicals were
- Dyubchenko,Nikulina,Terakh,Prosenko,Grigor'ev
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p. 1149 - 1155
(2008/09/17)
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- Reactions of perfluoro(2-methylpent-2-ene) and perfluoro(5-azanon-4-ene) with primary amines containing a 2,6-di-tert-butylphenol fragment
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Reactions of perfluoro(2-methylpent-2-ene) and perfluoro(5-azanon-4-ene) with 4-(2-aminoethyl)-2,6-di-tert-butylphenol and 4-(3-aminopropyl)-2,6-di-tert- butylphenol in acetonitrile in the presence of triethylamine gave the corresponding azetidine, 1,2-dihydroazete, and 1,2-dihydro-1,3-diazete derivatives, respectively. The reaction mechanisms, role of triethylamine, and factors affecting the intramolecular nucleophilic cyclization process are discussed.
- Furin,Krysin,Protsuk,Lopyrev
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p. 1429 - 1434
(2007/10/03)
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