5382-19-4

Basic information

• Product Name: 4-Chloropiperidine hydrochloride
• Synonyms: 1-METHYL-4-CHLORO-PIPERIDINE;4-CHLORO-1-METHYLPIPERIDINE;N-METHYL-4-CHLORO PIPERIDINE;4-Chloropiperidine hydrochloride;Piperidine, 4-chloro-, hydrochloride (1:1)
• CAS NO: 5382-19-4
• Molecular Formula: C5H11Cl2N
• Molecular Weight: 156.05
• Mol File: 5382-19-4.mol

Chemical Properties

• Melting Point: 200-201 °C
• Boiling Point: 216.7 °C at 760 mmHg
• Flash Point: 84.9 °C
• Appearance: /
• Vapor Pressure: 0.114mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Ethanol (Slightly) , Methanol (Slightly)
• CAS DataBase Reference: 4-Chloropiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropiperidine hydrochloride(5382-19-4)
• EPA Substance Registry System: 4-Chloropiperidine hydrochloride(5382-19-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5382-19-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloropiperidine hydrochloride is used as a reactant in the synthesis of indole and benzimidazole piperazines, which are histamine H4 receptor antagonists. These antagonists have potential therapeutic applications in treating various conditions, such as allergies, inflammatory disorders, and autoimmune diseases, by modulating the histamine H4 receptor's activity.

Synthesis Reference(s)

Synthesis, p. 324, 1996 DOI: 10.1055/s-1996-4221

InChI:InChI=1/C5H10ClN.ClH/c6-5-1-3-7-4-2-5;/h5,7H,1-4H2;1H

Upstream product

• 5570-77-4 4-chloro-1-methylpiperidine 

Relevant articles and documents

Synthesis of 1-tert-butyl-4-chloropiperidine: Generation of an N-tert-butyl group by the reaction of a dimethyliminium salt with methylmagnesium chloride

(Chemical Equation Presented) Two efficient routes to 1-tert-butyl-4- chloropiperidine are described. In the first route, the key thionyl chloride mediated chlorination reaction features the use of tetrabutyl-ammonium chloride as an additive that effectively suppresses the formation of an elimination-derived side product. In the second route, a novel alternative synthesis of 1-tert-butyl-4-chloropiperidine was developed in which the tertiary butyl group on the nitrogen is efficiently generated through the addition of methylmagnesium chloride to a dimethyliminium salt in 71% overall yield.

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