- Design and Synthesis of Fluorinated Dendrimers for Sensitive 19F MRI
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To achieve high sensitivity for 19F MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination and Williamson ether synthesis under mild conditions, a fluorinated dendrimer with 540 pseudosymmetrical fluorines was conveniently prepared without performing the group protection in a convergent way. The dendrimer is characterized by a strong 19F NMR peak and short relaxation times. Eventually, an appreciably enhanced 19F MRI at an extremely low concentration (18.5 μM) was achieved, which demonstrated the potential utility of such dendritic molecules in highly sensitive 19F MRI. (Chemical Equation Presented).
- Yu, Weijiang,Yang, Yuqi,Bo, Shaowei,Li, Yu,Chen, Shizhen,Yang, Zhigang,Zheng, Xing,Jiang, Zhong-Xing,Zhou, Xin
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- COPPER COUPLING REACTIONS OF 1,3-BIS(2-HYDROXYHEXAFLUORO-2-PROPYL)-5-IODOBENZENE AND ITS DERIVATIVES
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Attemts to homocouple 1,3-bis(2-hydroxyhexafluoro-2-propyl)-5-iodobenzene (diol iodide) with copper fail to give the desired biphenyl tetrol.However, the dimethyl ether derivative of the diol iodide reacts smoothly with copper to give the biphenyl tetrame
- Soulen, Robert L.,Griffith, James R.
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- A dendritic macromolecule fluorine - 19 magnetic resonance developer and its preparation method and application (by machine translation)
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The invention discloses a dendritic macromolecule fluorine - 19 magnetic resonance developer and its preparation method and application. Developer of the present invention is to fluorine-containing dendritic macromolecule as the skeleton, peripheral end group is connected with the functional molecule, its preparation method comprises the following steps: through the Lewis acid under the catalysis of the Friedel-crafts reaction of hexafluoroacetone with benzene will double-trifluoromethyl tertiary alcohol introduction benzene, in fuming sulfuric acid under the action of the iodination reaction, and then introduced into the propynyl structure through the coupling reaction, hydrogenating the resultant fluorine-containing structure unit Q; phosphorus tribromide in Q through the primary conversion of hydroxy group to bromine, then in hydroxy Q with the bromo generating ether linkage synthesis of 1st on behalf of the dendritic macromolecule, repeated brominated and ether generating reaction to obtain 2nd, three generations of dendritic macromolecule, finally through the brominated 3rd on behalf of the branched chain with the ligand through ether bond and to obtain the developer of the present invention. Developer of the present invention can be used for magnetic resonance imaging and the quantitative, visual, transmission and release and the like field. (by machine translation)
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Paragraph 0022; 0029-0030
(2017/08/25)
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- Syntheses and lipophilicities of tetraarylborate ions substituted with many trifluoromethyl groups
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Syntheses were investigated using various tetraarylborate ions with a large number of trifluoromethyl groups: tetrakisborate; tetrakisborate; tetrakisborate; and tetrakisborate ions.The preparation of Grignard reagents and the subsequent reaction with boron trifluoride etherate are importantsteps for a higher yield and easier isolation of the product.Sodium- and tetramethylammonium salts of these borate ions are soluble in halocarbon solvents such as dichloromethane, chloroform and 1,2-dibromotetrafluoroethane.
- Fujiki, Kanji,Kashiwagi, Mitsuyoshi,Miyamoto, Hideyuki,Sonoda, Akinari,Ichikawa, Junji,et al.
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p. 307 - 321
(2007/10/02)
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- PREPARATION OF 1,3,5-TRIS(2-HYDROXYHEXAFLUORO-2-PROPYL)BENZENE AND SOME OF ITS DERIVATIVES
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Grignard and lithium exchange methods have been used to prepare the polyfluoro alcohol, 1,3,5-tris(2-hydroxyhexafluoro-2-propyl)benzene.Preparation of the tris glycidyl ether of this alcohol and other derivatives are reported.
- Soulen, Robert L.,Griffith, James R.
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p. 203 - 210
(2007/10/02)
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