- Synthesis of β-ketonitriles, α,β-alkynones and biscabinols from esters using tert-butoxide-assisted C(=O)-C (i.e., acyl-C) coupling under ambient conditions
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We demonstrated the synthesis of β-ketonitriles, α,β- alkynones, and biscarbinols using tert-butoxide-assisted C(CO)-C (i.e., acyl-C) coupling of esters under ambient conditions. tert-Butoxide-assisted C(CO)-C (i.e., acyl-C) coupling of esters with cyanomethylenes and acetylenes under transition metal-free ambient conditions gives β-ketonitriles, α,β-alkynones and/or aryl bis(phenylethynyl)carbinols in moderate-to-good yields. It is noteworthy that this is a rapid, facile, and efficient process under ambient conditions, and use of cheap and stable starting materials.
- Kim, Bo Ram,Lee, Hyung-Geun,Kang, Seung-Beom,Jung, Kwang-Ju,Sung, Gi Hyeon,Kim, Jeum-Jong,Lee, Sang-Gyeong,Yoon, Yong-Jin
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p. 10331 - 10336
(2013/11/19)
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- Synthesis, double Michael-reaction and antimicrobial activity of cross-conjugated enyone
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Synthesis of the enyones 6(a-c) has been carried out by catalyzing the reactions with CeCl3. Phase transfer catalyzed double Michael addition reactions of the enyone 6a have also been investigated. The bisannulation could be enforced through th
- Rele, Dinesh N.,Baskaran,Korde, Shilpa S.,Vora, Jyoti D.,Trivedi, Girish K.
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p. 431 - 436
(2007/10/03)
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