53948-10-0

Basic information

• Product Name: Aristolactam BIII
• Synonyms: Aristolactam BIII
• CAS NO: 53948-10-0
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.316
• Mol File: 53948-10-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Aristolactam BIII(CAS DataBase Reference)
• NIST Chemistry Reference: Aristolactam BIII(53948-10-0)
• EPA Substance Registry System: Aristolactam BIII(53948-10-0)

Safety Data

• Hazardous Substances Data: 53948-10-0(Hazardous Substances Data)

Usage

Uses

Given the potential toxic effects of Aristolactam BIII, its uses are primarily focused on research and regulatory purposes to ensure the safety of herbal products and traditional medicines. However, it is important to note that due to its harmful effects, exposure to Aristolactam BIII should be limited.
Used in Pharmaceutical Research:
Aristolactam BIII is used as a research compound for studying its toxicological properties and potential role in renal fibrosis and urinary tract cancers. This helps in understanding the mechanisms of aristolochic acid nephropathy (AAN) and developing strategies to prevent or mitigate its harmful effects.
Used in Regulatory Compliance:
Aristolactam BIII is used as a marker for monitoring the presence of aristolactam alkaloids in herbal products and traditional medicines. Regulatory agencies may use this information to set safety standards and guidelines for the consumption of such products, ensuring that they do not contain harmful levels of aristolactam BIII and other aristolactam alkaloids.

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Relevant articles and documents

Synthesis of aristolactam analogues and evaluation of their antitumor activity

A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B

PHENANTHRENE LACTAM DERIVATIVES HAVING ANTICANCER ACTIVITY AND METHOD FOR THE PREPARATION THEREOF

The present invention relates to a phenanthrene lactam derivative having anticanter activity, a method for the preparation thereof, and a pharmaceutical composition comprising same.

Total synthesis of aristolactams via a one-pot Suzuki-Miyaura coupling/aldol condensation cascade reaction

(Chemical Equation Presented) A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki -Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is used to

The Intramolecular Aryne Cycloaddition Approach to Aporphinoids. A New Total Synthesis of Aristolactams and Phenanthrene Alkaloids

A new procedure for the total synthesis of aristolactams and phenanthrene alkaloids, based on the intramolecular Diels-Alder reaction between styrenes and arynes, is described.