Welcome to LookChem.com Sign In|Join Free

CAS

  • or

55-81-2

Post Buying Request

55-81-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

55-81-2 Usage

Chemical Properties

clear colorless to slightly yellow liquid

Uses

4-Methoxyphenethylamine an inhibitor of the deamination of tyramine and tryptamine. It is intermediates of ritodrine. ritodrine is an adrenergic β2 receptor agonists used to prevent premature birth.

Application

4-Methoxyphenethylamine was used in the synthesis of :pyrrolo[3,2-c]carbazolepoly(4-methoxyphenethylamine), required for the immobilization of nitrogenated bases and oligonucleotidesorganopolyphosphazenes such as poly[bis(4-methoxy benzylamino)polyphosphazene] and poly[bis(4-methoxyphenethylamino)polyphosphazene]4-methoxyphenethylamine was reacted with CDI and obtained N-substituted imidazolide intermediate.

Definition

ChEBI: 4-methoxyphenylethylamine is a primary amino compound consisting of ethylamine having a 4-methoxyphenyl substituent at the 2-position. It derives from a hydride of a 2-phenylethylamine.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 15, p. 214, 1972 DOI: 10.1021/jm00272a029

General Description

4-Methoxyphenethylamine inhibits the monoamine oxidase-catalyzed deamination of both tyramine and tryptamine.

Check Digit Verification of cas no

The CAS Registry Mumber 55-81-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 55-81:
(4*5)+(3*5)+(2*8)+(1*1)=52
52 % 10 = 2
So 55-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO/c1-11-9-4-2-8(3-5-9)6-7-10/h2-5H,6-7,10H2,1H3/p+1

55-81-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methoxyphenylethylamine

1.2 Other means of identification

Product number -
Other names 4-Methoxyphenethylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55-81-2 SDS

55-81-2Synthetic route

benzyl 4-methoxyphenethylcarbamate
198756-72-8

benzyl 4-methoxyphenethylcarbamate

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 1h;100%
p-methoxybenzylnitrile
104-47-2

p-methoxybenzylnitrile

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With aluminum (III) chloride; lithium aluminium tetrahydride In diethyl ether at 0 - 20℃;96%
With lithium borohydride; diisopropopylaminoborane In tetrahydrofuran for 18h; Reflux;94%
With [Ru(H)(BH4)(CO)(PPh3)(3-(di-tert-butylphosphino)-N-((1-methyl-1H-imidazol-2 yl)methyl)propylamine)]; hydrogen In isopropyl alcohol at 70℃; for 3h; Inert atmosphere; Autoclave;94%
lysichitalexin
31236-71-2

lysichitalexin

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With samarium diiodide; water; isopropylamine In tetrahydrofuran96%
N-[2-(4-methoxy-phenyl)-ethyl]-2-nitro-benzenesulfonamide

N-[2-(4-methoxy-phenyl)-ethyl]-2-nitro-benzenesulfonamide

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With potassium carbonate; thiophenol In acetonitrile at 50℃;95%
C12H14Cl3NO3
1258181-22-4

C12H14Cl3NO3

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
Stage #1: C12H14Cl3NO3 With chloro-trimethyl-silane; mischmetal In tetrahydrofuran for 2h; Inert atmosphere; Reflux;
Stage #2: With water In tetrahydrofuran for 0.0833333h; Alkaline conditions;
87%
1-methoxy-4-(2-nitro-vinyl)-benzene
3179-10-0

1-methoxy-4-(2-nitro-vinyl)-benzene

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; acetic acid; palladium on activated charcoal for 1h;71%
With hydrogen; carbon palladium at 85℃; under 37503 Torr;70%
(catalytic hydrogenation);
2-4-methoxyphenylethylcarbamic acid methyl ester
91247-71-1

2-4-methoxyphenylethylcarbamic acid methyl ester

A

7-methoxy-3,4-dihydro-2H-isoquinolin-1-one
22246-04-4

7-methoxy-3,4-dihydro-2H-isoquinolin-1-one

B

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With PPA at 145℃; for 0.166667h;A 59%
B 30%
3-(4-methoxy-phenyl)propionamide
25413-27-8

3-(4-methoxy-phenyl)propionamide

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With sodium hydroxide; bromine In water at 70 - 80℃; for 0.25h;53%
With sodium hypobromide
With alkaline sodium hypochlorite
4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide
141666-92-4

4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With titanium tetrachloride In tetrahydrofuran for 2.5h; Heating;40%
(E)-1-methoxy-4-(2-nitrovinyl)benzene
3179-10-0, 5576-97-6

(E)-1-methoxy-4-(2-nitrovinyl)benzene

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With samarium diiodide; water; isopropylamine In tetrahydrofuran36%
With sulfuric acid; palladium; acetic acid Hydrogenation;
bei der elektrochemischen Reduktion;
With lithium aluminium tetrahydride
ethyleneimine
151-56-4

ethyleneimine

methoxybenzene
100-66-3

methoxybenzene

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With aluminium trichloride
4-Methoxystyrene
637-69-4

4-Methoxystyrene

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With chloroform; nitrosylchloride Hydrieren des Reaktionsprodukts an Raney-Nickel in Methanol;
Multi-step reaction with 3 steps
1: NOCl, HCl / diethyl ether
2: Et3N / diethyl ether
3: LiAlH4 / diethyl ether
View Scheme
With D-Glucose; ammonia; oxygen In aq. phosphate buffer at 30℃; for 10h; Green chemistry; regioselective reaction;
Multi-step reaction with 3 steps
1: oxygen; styrene monooxygenase / Enzymatic reaction
2: styrene oxide isomerase / Enzymatic reaction
3: ammonia; ω-transaminase; L-alanine dehydrogenase / Enzymatic reaction
View Scheme
4-methoxymandelonitrile
33646-40-1

4-methoxymandelonitrile

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With hydrogenchloride; ethanol; platinum Hydrogenation;
3-(4-methoxyphenyl)propanoic acid
1929-29-9

3-(4-methoxyphenyl)propanoic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With sodium azide; chloroform; sulfuric acid
Multi-step reaction with 2 steps
1: thionyl chloride; chloroform / nachfolgend Behandlung mit Natriumhydroxyd in Ammoniak
2: alkaline sodium hypochlorite
View Scheme
Multi-step reaction with 3 steps
1: chloroform; PCl5
2: diethyl ether; NH3
3: bromine; NaOH-solution / 55 °C
View Scheme
4-methoxybenzoyl cyanide
14271-83-1

4-methoxybenzoyl cyanide

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With sulfuric acid; palladium; acetic acid Hydrogenation;
2-(4-methoxyphenyl)acetaldehyde oxime
3353-51-3

2-(4-methoxyphenyl)acetaldehyde oxime

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With sulfuric acid; palladium; acetic acid Hydrogenation;
acetoxy-(4-methoxy-phenyl)-acetonitrile
99843-19-3

acetoxy-(4-methoxy-phenyl)-acetonitrile

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With sulfuric acid; palladium; acetic acid Hydrogenation;
p-methoxybenzylnitrile
104-47-2

p-methoxybenzylnitrile

A

4-methoxy-N-[2-(4-methoxyphenyl)ethyl]benzeneethanamine
122380-12-5

4-methoxy-N-[2-(4-methoxyphenyl)ethyl]benzeneethanamine

B

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With nickel Hydrogenation;
1-(2-Chloroethyl)-4-methoxybenzene
18217-00-0

1-(2-Chloroethyl)-4-methoxybenzene

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With ammonia
With ethanol; ammonia at 100℃;
Bis-(β-nitroso-4-methoxy-styrol)
2742-79-2

Bis-(β-nitroso-4-methoxy-styrol)

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether
2-[2-(4-methoxyphenyl)ethyl]-1H-isoindole-1,3(2H)-dione
169614-59-9

2-[2-(4-methoxyphenyl)ethyl]-1H-isoindole-1,3(2H)-dione

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 70℃;
[2-(4-Methoxy-phenyl)-ethyl]-phosphoramidic acid diethyl ester
86423-53-2

[2-(4-Methoxy-phenyl)-ethyl]-phosphoramidic acid diethyl ester

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With hydrogenchloride at 80 - 85℃; for 1.5h; Yield given;
2-amino-1-<4-methoxy-phenyl>-ethanone-(1)-hydrochloride

2-amino-1-<4-methoxy-phenyl>-ethanone-(1)-hydrochloride

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
With sulfuric acid; palladium; acetic acid Hydrogenation;
4-methoxy-phenylacetaldoxime

4-methoxy-phenylacetaldoxime

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

sulfuric acid
7664-93-9

sulfuric acid

(E)-1-methoxy-4-(2-nitrovinyl)benzene
3179-10-0, 5576-97-6

(E)-1-methoxy-4-(2-nitrovinyl)benzene

acetic acid
64-19-7

acetic acid

palladium

palladium

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
Hydrogenation;
sulfuric acid
7664-93-9

sulfuric acid

4-methoxybenzoyl cyanide
14271-83-1

4-methoxybenzoyl cyanide

acetic acid
64-19-7

acetic acid

palladium

palladium

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
Hydrogenation;
ethanol
64-17-5

ethanol

(E)-1-methoxy-4-(2-nitrovinyl)benzene
3179-10-0, 5576-97-6

(E)-1-methoxy-4-(2-nitrovinyl)benzene

platinum

platinum

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

Conditions
ConditionsYield
Hydrogenation;
3-(4-methoxy-phenyl)propionamide
25413-27-8

3-(4-methoxy-phenyl)propionamide

bromine
7726-95-6

bromine

furan-2,3,5(4H)-trione pyridine (1:1)

furan-2,3,5(4H)-trione pyridine (1:1)

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(4-methoxyphenyl)acetaldehyde oxime
3353-51-3

2-(4-methoxyphenyl)acetaldehyde oxime

sodium amalgam

sodium amalgam

alcoholic glacial acetic acid

alcoholic glacial acetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

methyl chloroformate
79-22-1

methyl chloroformate

2-4-methoxyphenylethylcarbamic acid methyl ester
91247-71-1

2-4-methoxyphenylethylcarbamic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine Inert atmosphere; Cooling with ice;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;99%
With triethylamine In tetrahydrofuran for 24h; Ambient temperature;95%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-(4-methoxyphenyl)ethan-1-aminechloroacetate
17639-50-8

2-(4-methoxyphenyl)ethan-1-aminechloroacetate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane Ambient temperature;100%
With triethylamine In dichloromethane at 0 - 20℃; for 6h; Reflux;85%
With triethylamine In dichloromethane at 0 - 20℃; for 4h;76%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

chloroacetic acid
79-11-8

chloroacetic acid

4-formyl-3,5-dimethoxyphenoxy-Merrifield resin

4-formyl-3,5-dimethoxyphenoxy-Merrifield resin

2-(4-methoxyphenyl)ethan-1-aminechloroacetate
17639-50-8

2-(4-methoxyphenyl)ethan-1-aminechloroacetate

Conditions
ConditionsYield
Stage #1: 4-Methoxyphenethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride In acetic acid; N,N-dimethyl-formamide at 20℃; for 69h; Solid phase reaction; reductive amination;
Stage #2: chloroacetic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 15h; Solid phase reaction; acylation;
Stage #3: With dimethylsulfide; water; trifluoroacetic acid In dichloromethane at 20℃; for 15h; Solid phase reaction; cleavage of amide;
100%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

butyric acid
107-92-6

butyric acid

4-formyl-3,5-dimethoxyphenoxy-Merrifield resin

4-formyl-3,5-dimethoxyphenoxy-Merrifield resin

N-butanoyl-2-(4-methoxyphenyl)ethanamine

N-butanoyl-2-(4-methoxyphenyl)ethanamine

Conditions
ConditionsYield
Stage #1: 4-Methoxyphenethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride In acetic acid; N,N-dimethyl-formamide at 20℃; for 69h; Solid phase reaction; reductive amination;
Stage #2: butyric acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 15h; Solid phase reaction; acylation;
Stage #3: With dimethylsulfide; water; trifluoroacetic acid In dichloromethane at 20℃; for 15h; Solid phase reaction; cleavage of amide;
100%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

piperidine-1,4-dicarboxylic acid mono-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl) ester
350716-60-8

piperidine-1,4-dicarboxylic acid mono-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl) ester

4-[2-(4-methoxy-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester
350717-38-3

4-[2-(4-methoxy-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In chloroform; N,N-dimethyl-formamide at 20℃; for 16h;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-ethylamine
121778-75-4

N-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-ethylamine

Conditions
ConditionsYield
With guanidine hydrochloride In ethanol at 35 - 40℃; for 0.0166667h;100%
With sulfonic acid-functionalized nanoporous titania catalyst In neat (no solvent) at 20℃; for 0.266667h; chemoselective reaction;96%
With triethylamine In dichloromethane at 20℃; for 1h;96%
5-((3-chloro-4-fluorophenylsulfonamido)methyl)picolinic acid

5-((3-chloro-4-fluorophenylsulfonamido)methyl)picolinic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

5-[(3-chloro-4-fluorobenzene)sulfonamidomethyl]-N-[2-(4-methoxyphenyl)ethyl] pyridine-2-carboxamide

5-[(3-chloro-4-fluorobenzene)sulfonamidomethyl]-N-[2-(4-methoxyphenyl)ethyl] pyridine-2-carboxamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;99.94%
acetic anhydride
108-24-7

acetic anhydride

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N-(4-methoxyphenylethyl)acetamide
54815-19-9

N-(4-methoxyphenylethyl)acetamide

Conditions
ConditionsYield
at 20 - 30℃; for 1h;99%
With triethylamine In dichloromethane for 2h; Ambient temperature;86%
With triethylamine In dichloromethane at 20℃;85%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

ethyl-N-<2-(4-methoxyphenyl)ethyl>-carbamate
136390-01-7

ethyl-N-<2-(4-methoxyphenyl)ethyl>-carbamate

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 25℃;99%
With pyridine In dichloromethane at 0 - 20℃;99%
With triethylamine In dichloromethane at 0 - 25℃; for 1h;98.3%
N-((tert-butyloxy)carbonyl)iminodiacetic acid
56074-20-5

N-((tert-butyloxy)carbonyl)iminodiacetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N-((tert-butyloxy)carbonyl)-N'-(2-(4-methoxyphenyl)ethyl)iminodiacetic acid monoamide
188625-14-1

N-((tert-butyloxy)carbonyl)-N'-(2-(4-methoxyphenyl)ethyl)iminodiacetic acid monoamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 20h; Substitution;99%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-methoxy-5-chlorobenzoyl chloride
29568-33-0

2-methoxy-5-chlorobenzoyl chloride

5-chloro-2-methoxy-N-(2-(4-methoxyphenyl)ethyl)benzamide
158751-77-0

5-chloro-2-methoxy-N-(2-(4-methoxyphenyl)ethyl)benzamide

Conditions
ConditionsYield
With pyridine at 20℃; for 1h;99%
carbon disulfide
75-15-0

carbon disulfide

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

phenylpropynoic acid ethyl ester
2216-94-6

phenylpropynoic acid ethyl ester

(Z)-5-benzylidene-3-[2-(4-methoxyphenyl)ethyl]-2-thioxo-thiazolidin-4-one

(Z)-5-benzylidene-3-[2-(4-methoxyphenyl)ethyl]-2-thioxo-thiazolidin-4-one

Conditions
ConditionsYield
Stage #1: carbon disulfide; 4-Methoxyphenethylamine In isopropyl alcohol at 20℃; for 6h;
Stage #2: phenylpropynoic acid ethyl ester; tributylphosphine In isopropyl alcohol at 20℃; Further stages.;
99%
(3,4-Dimethoxyphenyl)acetic acid
93-40-3

(3,4-Dimethoxyphenyl)acetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(3,4-dimethoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
13397-02-9

2-(3,4-dimethoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
In 5,5-dimethyl-1,3-cyclohexadiene for 16h; Reflux; Inert atmosphere;94%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
340218-64-6

2-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
4-Methoxyphenylacetic acid
104-01-8

4-Methoxyphenylacetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(4-methoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
41898-71-9

2-(4-methoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine
3,4,5-trimethoxyphenyl acetic acid
951-82-6

3,4,5-trimethoxyphenyl acetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N-[2-(4-methoxyphenyl)ethyl]-2-(3,4,5-trimethoxyphenyl)acetamide
1037943-04-6

N-[2-(4-methoxyphenyl)ethyl]-2-(3,4,5-trimethoxyphenyl)acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-naphthylacetic acid
581-96-4

2-naphthylacetic acid

N-[2-(4-methoxyphenyl)ethyl]-2-(naphthalen-2-yl)acetamide
1037942-89-4

N-[2-(4-methoxyphenyl)ethyl]-2-(naphthalen-2-yl)acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((4-methoxyphenethyl)amino)-2-oxoethyl)phosphonate
1426294-40-7

diisopropyl (2-((4-methoxyphenethyl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 4-Methoxyphenethylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
racemic trans-1-(tert-butoxycarbonyl)pyrrolidine-3,4-dicarboxylic acid

racemic trans-1-(tert-butoxycarbonyl)pyrrolidine-3,4-dicarboxylic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

tert-butyl trans-3,4-bis((4-methoxyphenethyl)carbamoyl)pyrrolidine-1-carboxylate

tert-butyl trans-3,4-bis((4-methoxyphenethyl)carbamoyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere;99%
3,3,3-triphenylpropionyl chloride
33166-49-3

3,3,3-triphenylpropionyl chloride

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N-[2-(4-methoxy-phenyl)-ethyl]-3,3,3-triphenyl-propionamide

N-[2-(4-methoxy-phenyl)-ethyl]-3,3,3-triphenyl-propionamide

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 48h;98.9%
caffeic acid
331-39-5

caffeic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

7′-(3′,4′-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide

7′-(3′,4′-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide

Conditions
ConditionsYield
Stage #1: caffeic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.25h; Cooling with ice;
Stage #2: 4-Methoxyphenethylamine In N,N-dimethyl-formamide at 20℃;
98.8%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

3,4-(methylenedioxy)cinnamic acid
2373-80-0

3,4-(methylenedioxy)cinnamic acid

C19H19NO4

C19H19NO4

Conditions
ConditionsYield
Stage #1: 3,4-(methylenedioxy)cinnamic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.25h; Cooling with ice;
Stage #2: 4-Methoxyphenethylamine In N,N-dimethyl-formamide at 20℃;
98.4%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(4-methoxycyclohexa-1,4-dienyl)ethylamine
67175-79-5

2-(4-methoxycyclohexa-1,4-dienyl)ethylamine

Conditions
ConditionsYield
With ammonia; sodium In tetrahydrofuran; ethanol at -78℃; Birch reduction;98%
With ammonia; lithium In tert-butyl alcohol at -78℃; for 6h;95%
With ammonia; lithium In ethanol at -78℃; for 15h;94%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide
141666-92-4

4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h; Tosylation;98%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;93%
Stage #1: 4-Methoxyphenethylamine With sodium carbonate In water for 0.5h; pH=8 - 9;
Stage #2: p-toluenesulfonyl chloride In water
91%
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid
50921-39-6

1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide
916923-23-4

1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 3 - 20℃;98%
1,3-benzodioxole-5-acetic acid
2861-28-1

1,3-benzodioxole-5-acetic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
1395084-65-7

2-(2H-1,3-benzodioxol-5-yl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;98%
In 5,5-dimethyl-1,3-cyclohexadiene for 16h; Reflux; Inert atmosphere;80%
1-acetyl-9H-β-carboline-3-carboxylic acid

1-acetyl-9H-β-carboline-3-carboxylic acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

marinacarboline A
1338578-37-2

marinacarboline A

Conditions
ConditionsYield
With triethylamine; diethyl dicarbonate In N,N-dimethyl-formamide at -10 - 20℃; Inert atmosphere;98%
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at -10 - 25℃; for 12.5h;96%
phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

1-(2-(4-methoxyphenyl)ethyl)-3-phenylthiourea
351498-91-4

1-(2-(4-methoxyphenyl)ethyl)-3-phenylthiourea

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;98%
(2R,3R,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate
1421782-15-1

(2R,3R,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

(2S,3S,4R)-1-(4-methoxyphenethyl)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)piperidine
1600532-65-7

(2S,3S,4R)-1-(4-methoxyphenethyl)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)piperidine

Conditions
ConditionsYield
at 80 - 90℃;98%

55-81-2Relevant articles and documents

A new amide from Zanthoxylum armatum

Kalia, Narendra K.,Singh, Bikram,Sood, Ram P.

, p. 311 - 312 (1999)

A new amide designated as armatamide (1) - along with two lignans, asarinin and fargesin, α- and β-amyrins, lupeol, and β-sitosterol-β-D- glucoside - has been isolated from the bark of Zanthoxylum armatum. The structure of the new compound was deduced by spectral and chemical analysis as N-(4'-methoxyphenyl ethyl)-3, 4-methylenedioxy cinnamoyl amide.

A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation

Formenti, Dario,Mocci, Rita,Atia, Hanan,Dastgir, Sarim,Anwar, Muhammad,Bachmann, Stephan,Scalone, Michelangelo,Junge, Kathrin,Beller, Matthias

supporting information, p. 15589 - 15595 (2020/10/02)

Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700 °C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.g. 70 °C, 20 bar H2). The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested commercial catalysts, for example, Raney Nickel and even noble-metal-based systems in these transformations.

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Betori, Rick C.,May, Catherine M.,Scheidt, Karl A.

supporting information, p. 16490 - 16494 (2019/11/03)

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 55-81-2