- Utilization of transition metal fluoride-based solid support catalysts for the synthesis of sulfonamides: Carbonic anhydrase inhibitory activity and: In silico study
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The applications of solid support catalysts in catalyzing organic reactions are well-evident. In the present study, we explored a transition metal fluoride (FeF3) adsorbed on molecular sieves (4 ?) as a solid support catalyst for the preparation of sulfon
- Al-Rashida, Mariya,Ali, Deedar,Amjad, Sayyeda Tayyeba,Hameed, Abdul,Iftikhar, Shafia,Iqbal, Jamshed,Naseer, Muhammad Moazzam,Shafique, Zainab,Shah, Muhammad Raza,Sindhu, Tayyaba Allamgir
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p. 3165 - 3179
(2022/02/05)
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- Transition-metal-free direct amination of simple arenes with sulfonyl azides
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A metal-free green protocol has been developed for amination of simple arenes using arylsulfonyl azides via a nitrene transfer process under solvent free conditions at 130 °C releasing N2 gas as the sole by-product.
- Wang, Lianggui,Borah, Arun Jyoti,Yan, Guobing
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supporting information
p. 1353 - 1355
(2015/03/04)
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- N-sulfonated derivatives of 2,3-xylidine as suitable antibacterial agents
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The objective of the current research effort was to unravel the antibacterial potential of some newly synthesized sulfonamides. 2,3-Dimethylaniline (2,3-xylidine, 1) was reacted with different sulfonyl chlorides (2a-g) under dynamic control of pH (9-10) in aqueous alkaline medium to generate a series of N-sulfonated derivatives of 2,3-xylidine (3a-g). The plausible structures of the synthesized derivatives were corroborated by contemporary spectral techniques e.g. IR,1H-NMR and EIMS. Moreover, N-sulfonated derivatives were screened against different gram negative and positive bacterial strains to evaluate their inhibitory potential. They depicted good to moderate inhibitory potential, especially, N-(2,3-dimethylphenyl)methanesulfonamide (3a), N-(2,3- dimethylphenyl)-4-methylbenzenesulfonamide (3b), N-(2,3-dimethylphenyl)-4- bromobenzenesulfonamide (3d) and N-(2,3-dimethylphenyl)naphthalene-2-yl-sulfonamide (3f) were amongst the potent inhibitors as compared to standard; Ciprofloxacin.
- Abbasi, Muhammad Athar,Sheeza, Anam,Aziz-Ur-Rehman,Siddiqui, Sabahat Zahra,Khan, Khalid Mohammed,Malik, Rabia,Ahmad, Irshad
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p. 541 - 548
(2015/08/04)
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- Half-sandwich scorpionates as nitrene transfer catalysts
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Scorpionate complexes of the middle to late 3d transition metals [(L)M(NCMe)3](BF4)n (M = Mn, Fe, Co, Ni: 1 M, L = tris(3,5-dimethylpyrazol-1-yl)methane, TpmMe,Me, n = 2; 2M, L = tris(3-phenylpyrazol-1-yl)methane, TpmPh, n = 2; 3M except 3Mn, L = hydrotris(3,5-dimethylpyrazol-1-yl) borate, [TpMe,Me]-, n = 1; 4M, L = hydrotris(3-phenyl-5-methylpyrazol-1-yl)borate, [TpPh,Me] -, n = 1) were examined as catalysts for styrene aziridination and THF amination using phenyl-N-tosyliodinane as a nitrene donor. [(Tpm Me,Me)Fe(NCMe)3](BF4)2 (1 Fe) was identified as the most active catalyst, giving nearly quantitative nitrene transfer yields at 5 mol % loadings. The reactivity of 1Fe with a wider range of organic substrates was also explored, and a striking observation was strong selectivity for aromatic rather than benzylic amination for alkylaromatic substrates.
- Liang, Shengwen,Jensen, Michael P.
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p. 8055 - 8058
(2013/02/22)
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- Identification of novel glycine sulfonamide antagonists for the EP1 receptor
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A high-throughput screen targeting the EP1 receptor identified non-acidic glycine sulfonamide derivative 2a with a pKi of 6.2. Analogue synthesis allowed a thorough investigation of the structure-activity relationship (SAR) and led to a 100-fold increase in recombinant potency.
- McKeown, Stephen C.,Hall, Adrian,Blunt, Richard,Brown, Susan H.,Chessell, Iain P.,Chowdhury, Anita,Giblin, Gerard M.P.,Healy, Mark P.,Johnson, Matthew R.,Lorthioir, Olivier,Michel, Anton D.,Naylor, Alan,Lewell, Xiao,Roman, Shilina,Watson, Stephen P.,Winchester, Wendy J.,Wilson, Richard J.
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p. 1750 - 1754
(2007/10/03)
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