54027-45-1

Upstream product

• 95-47-6 o-xylene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 98-59-9 p-toluenesulfonyl chloride 
• 87-59-2 2,3-Dimethylaniline 
• 941-55-9 4-toluenesulfonyl azide 

Relevant academic research and scientific papers

Utilization of transition metal fluoride-based solid support catalysts for the synthesis of sulfonamides: Carbonic anhydrase inhibitory activity and: In silico study

The applications of solid support catalysts in catalyzing organic reactions are well-evident. In the present study, we explored a transition metal fluoride (FeF3) adsorbed on molecular sieves (4 ?) as a solid support catalyst for the preparation of sulfon

Transition-metal-free direct amination of simple arenes with sulfonyl azides

A metal-free green protocol has been developed for amination of simple arenes using arylsulfonyl azides via a nitrene transfer process under solvent free conditions at 130 °C releasing N2 gas as the sole by-product.

N-sulfonated derivatives of 2,3-xylidine as suitable antibacterial agents

The objective of the current research effort was to unravel the antibacterial potential of some newly synthesized sulfonamides. 2,3-Dimethylaniline (2,3-xylidine, 1) was reacted with different sulfonyl chlorides (2a-g) under dynamic control of pH (9-10) in aqueous alkaline medium to generate a series of N-sulfonated derivatives of 2,3-xylidine (3a-g). The plausible structures of the synthesized derivatives were corroborated by contemporary spectral techniques e.g. IR,1H-NMR and EIMS. Moreover, N-sulfonated derivatives were screened against different gram negative and positive bacterial strains to evaluate their inhibitory potential. They depicted good to moderate inhibitory potential, especially, N-(2,3-dimethylphenyl)methanesulfonamide (3a), N-(2,3- dimethylphenyl)-4-methylbenzenesulfonamide (3b), N-(2,3-dimethylphenyl)-4- bromobenzenesulfonamide (3d) and N-(2,3-dimethylphenyl)naphthalene-2-yl-sulfonamide (3f) were amongst the potent inhibitors as compared to standard; Ciprofloxacin.

Half-sandwich scorpionates as nitrene transfer catalysts

Scorpionate complexes of the middle to late 3d transition metals [(L)M(NCMe)3](BF4)n (M = Mn, Fe, Co, Ni: 1 M, L = tris(3,5-dimethylpyrazol-1-yl)methane, TpmMe,Me, n = 2; 2M, L = tris(3-phenylpyrazol-1-yl)methane, TpmPh, n = 2; 3M except 3Mn, L = hydrotris(3,5-dimethylpyrazol-1-yl) borate, [TpMe,Me]-, n = 1; 4M, L = hydrotris(3-phenyl-5-methylpyrazol-1-yl)borate, [TpPh,Me] -, n = 1) were examined as catalysts for styrene aziridination and THF amination using phenyl-N-tosyliodinane as a nitrene donor. [(Tpm Me,Me)Fe(NCMe)3](BF4)2 (1 Fe) was identified as the most active catalyst, giving nearly quantitative nitrene transfer yields at 5 mol % loadings. The reactivity of 1Fe with a wider range of organic substrates was also explored, and a striking observation was strong selectivity for aromatic rather than benzylic amination for alkylaromatic substrates.

Identification of novel glycine sulfonamide antagonists for the EP1 receptor

A high-throughput screen targeting the EP1 receptor identified non-acidic glycine sulfonamide derivative 2a with a pKi of 6.2. Analogue synthesis allowed a thorough investigation of the structure-activity relationship (SAR) and led to a 100-fold increase in recombinant potency.