540529-26-8Relevant articles and documents
Facile direct synthesis of amides from trichloroethyl esters using catalytic DBU
La, Minh Thanh,Kim, Hee-Kwon
, p. 1135 - 1141 (2018/11/25)
A practical method for the direct synthesis of amide compounds is described. Using small quantities of DBU as a catalyst, the direct conversion of 2,2,2-trichloroethyl esters to their corresponding amides was readily achieved. Based on this protocol, various amide compounds were successfully synthesized in high yield, suggesting a promising approach for the practical one-pot aminolysis from 2,2,2-trichloroethyl protected esters.
Transamidation of primary amides with amines using hydroxylamine hydrochloride as an inorganic catalyst
Allen, C. Liana,Atkinson, Benjamin N.,Williams, Jonathan M. J.
supporting information; experimental part, p. 1383 - 1386 (2012/04/18)
Metal-free catalysis: A method for the transamidation of primary amides with primary or secondary amines provides access to secondary and tertiary amides, by utilizing catalytic quantities of hydroxylamine hydrochloride to activate the chemically robust primary amide group (see scheme). A mechanism of primary amide activation through a hydrogen-bonding complex is proposed. Copyright
Direct synthesis of imines from alcohols and amines with liberation of H2
Gnanaprakasam, Boopathy,Zhang, Jing,Milstein, David
supporting information; experimental part, p. 1468 - 1471 (2010/05/02)
"Chemical equation presented" A clean sweep: Aryl and aliphatic mines can be synthesized directly and efficiently from alcohols and amines under mild, neutral conditions with the liberation of only molecular hydrogen and water (see scheme; R=isopropyl, tert-butyl). This general, environmentally benign reaction is catalyzed by a de-aromatized ruthenium PNP pincer complex (0.2 mol%), and can proceed in toluene under an inert atmosphere or under air.
