104-84-7

Basic information

• Product Name: Benzenemethanamine,4-methyl-
• Synonyms: Benzylamine,p-methyl- (8CI);((4-Methylphenyl)methyl)amine;4-Aminomethyltoluene;4-Methylbenzenemethanamine;NSC 66562;p-Methylbenzenemethanamine;p-Methylbenzylamine;p-Tolylmethylamine
• CAS NO: 104-84-7
• Molecular Formula: C₈H₁₁N
• Molecular Weight: 122.187
• EINECS: 203-243-2
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 104-84-7.mol
• Article Data: 135

Chemical Properties

• Melting Point: 13℃
• Boiling Point: 194.999 °C at 760 mmHg
• Flash Point: 75 °C
• Appearance: colorless to yellow clear liquid
• Density: 0.964 g/cm³
• Vapor Pressure: 0.429mmHg at 25°C
• Refractive Index: n20/D 1.534(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 9.21±0.10(Predicted)
• Water Solubility: slightly soluble
• BRN: 956670
• CAS DataBase Reference: Benzenemethanamine,4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine,4-methyl-(104-84-7)
• EPA Substance Registry System: Benzenemethanamine,4-methyl-(104-84-7)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R34:
• Safety Statements: S26:; S36/37/39:; S45:
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 104-84-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

Uses

Different sources of media describe the Uses of 104-84-7 differently. You can refer to the following data:
1. 4-Methylbenzylamine is a methylated benzylamine used in the preparation of various bioactive compounds such as anticonvulsants. 4-Methylbenzylamine has been shown to stimulate food consumption and cou nteract the hypophagic effects of amphetamine acting on brain Shaker-like Kv1.1 channels.
2. The reactions of 1-hexanol with benzylamine and with 4-methylbenzylamine led to the corresponding imines in moderate yields. 4-methylbenzylamine in ethanol/water solution (1:4) as simultaneously absorbing and buffering background electrolyte with detection at 210 nm was found suitable for determination of the individual compounds in determination by capillary zone electrophoresis with indirect detection. Synthesis of benzimidazoles uses 4-methylbenzylamine (R 1 =4-MeBn) and 4-chlorophenyl isothiocyanate (R 2 =4-ClPh) as building blocks.

InChI:InChI=1/C8H11N/c1-7-2-4-8(6-9)5-3-7/h2-5H,6,9H2,1H3/p+1

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 619-55-6 para-methylbenzamide 
• 827-71-4 4-methyl-benzimidic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 589-18-4 4-Methylbenzyl alcohol 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 101207-45-8 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione 
• 17271-89-5 4-methylphenylmethylazide 
• 40739-81-9 p-tolualdehyde p-toluenesulfonylhydrazone 
• 104-87-0 4-methyl-benzaldehyde 
• 29559-27-1 1-methyl-4-(nitromethyl)benzene 
• 103560-15-2 N,N-bis(trimethylsilyl)-4-methylbenzylamine 
• 124225-47-4 4-methylbenzylammonium 
• 114444-46-1 C₁₄H₁₃NO 

Downstream Products

• 71022-60-1 (E)-N-(4-methylbenzylidene)(4-methylphenyl)methanamine 
• 41882-47-7 N-benzylidene-1-(p-tolyl)methanamine 
• 35305-48-7 1-(4-methylbenzyl)-3-phenyl-2-thiourea 
• 58015-09-1 N₁,N₂-bis(4-methylbenzyl)ethane-1,2-diamine 
• 112971-17-2 3-((4-methylbenzyl)amino)propanenitrile 
• 99981-59-6 3-[{(4-methylphenyl)methyl}amino]propanamide 
• 41882-22-8 N-(p-Methylbenzyl)-m-chlorbenzamid 
• 114479-34-4 N-<4-Methyl-benzyl>-glycin 
• 16735-75-4 1,3-bis-(4-methyl-benzyl)-thiourea 
• 33312-11-7 N,N'-bis-(4-methyl-benzyl)-3,3'-disulfanediyl-bis-propionamide 
• 70325-64-3 4-[4-chloro-3-(4-methylbenzylsulfamoyl)-phenyl]-4-oxobutanoic acid 
• 95821-48-0 N,N',N''-Tris-<4-methyl-benzyl>-guanidin 
• 71416-81-4 Cyclohex-1-ene-1,2-dicarboxylic acid 1-[(4-chloro-2-fluoro-phenyl)-amide] 2-(4-methyl-benzylamide) 
• 72359-31-0 1-(4-methylbenzyl)-4,6-diphenyl-2-pyridone 

Relevant articles and documents

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Copper catalyzed reduction of azides with diboron under mild conditions

We report herein the first Cu catalyzed reduction of azides with B2pin2 (pin = pinacolato) as the reductant under very mild conditions. A series of primary amines and amides were obtained in moderate to excellent yields with high chemoselectivity and good functional group tolerance. This reaction can be performed with a cheap copper salt, a simple NHC ligand and a diboron reagent.

Preparation of a magnetic mesoporous Fe3O4-Pd@TiO2 photocatalyst for the efficient selective reduction of aromatic cyanides

Herein, a hierarchical magnetic mesoporous microsphere was successfully prepared as a photocatalyst via a simple and reproducible route. Typically, Pd nanoparticles (NPs) were evenly dispersed on the surface of a magnetic Fe3O4 microsphere and then coated with a porous anatase-TiO2 shell to form Fe3O4-Pd@TiO2. The core-shell structure could efficiently suppress the conglomeration of Pd NPs during the calcination process at high temperatures as well as the shedding of Pd during the catalytic reaction process in the liquid phase. The as-prepared photocatalyst was characterized by TEM, XRD, XPS, VSM, and N2 adsorption-desorption. Fe3O4-Pd@TiO2 exhibits high photocatalytic activity for the selective reduction of aromatic cyanides to aromatic primary amines in an acidic aqueous solution. Moreover, this magnetic photocatalyst could be easily recovered from the reaction mixture by an external magnet and reused five times without significant reduction in its activity. The superior photocatalytic efficiency of the proposed photocatalyst may be attributed to its high charge separation efficiency and charge transfer rate, which are caused by the Schottky junction and large interface area. The results indicate that the strategy of coating the active noble metal sites with a mesoporous semiconductor shell has a significant potential for application in metal-semiconductor-based photocatalytic reactions.

Method for preparing primary amine by catalytically reducing nitrile compounds through nano-porous palladium catalyst

The invention belongs to the technical field of heterogeneous catalysis, and provides a method for preparing primary amine by catalytically reducing nitrile compounds with a nano-porous palladium catalyst. According to the invention, aromatic and aliphatic nitrile compounds are adopted as raw materials, nano-porous palladium is adopted as a catalyst, ammonia borane is adopted as a hydrogen source, no additional additive is added, and selective hydrogenation is performed to prepare the corresponding primary amine. The method provided by the invention has the beneficial effects of mild reaction conditions, no additive, environmental protection, no need of hydrogen, simple operation, stable hydrogen source, safety, harmlessness, high conversion rate, high selectivity and good catalyst stability, and makes industrialization possible.

Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application

Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.