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54057-59-9

Articles about 54057-59-9Total 4 be found

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Synthesis of novel cinnamoyl amides using a solvent-free microwave-assisted method
A novel series of potential biologically active new cinnamoyl amides were synthesized in good yield and short reaction times. We have studied the one-pot, solvent-free reaction of cinnamic acid derivatives with aromatic amines using 1,3-dicyclohexylcarbodiimide under microwave irradiation in the presence of small quantities of dimethylformamide to improve energy transfer.
Pellon, Rolando F.,Docampo, Maite L.
p. 537 - 552
(2013/01/15)

Design, synthesis and inhibitory activities of 8-(substituted styrolformamido) phenyl-xanthine derivatives on monoamine oxidase B
The design and synthesis of two series of 8-(substituted styrol-formamido)phenyl-xanthine derivatives are described. Their in vitro monoamine oxidase B (MAO-B) inhibition were tested and the effect of substituents on the N-7, phenyl and the substituted positions are discussed. It was observed that compound 9b displayed significant MAO-B inhibition activity and selectivity, fluorine substitution plays a key role in the selectivity of MAO-B inhibition, and the styrol-formamido group at position-3′ may enhance the activity and selectivity of 8-phenyl-xanthine analogues. These results suggest that such compounds may be utilized for the development of new candidate MAO-B inhibitors for treatment of Parkinson's disease.
Hu, Suwen,Nian, Siyun,Qin, Kuiyou,Xiao, Tong,Li, Ngna,Qi, Xiaolu,Ye, Faqing,Liang, Guang,Hu, Guoxin,He, Jincai,Yu, Yinfei,Song, Bo
experimental part
p. 385 - 390
(2012/05/04)

SYNTHESIS AND ANTIALLERGIC ACTIVITY IN A SERIES OF CINNAMIC ACID
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Saraf, A. S.,Simonyan, A. V.
p. 598 - 602
(2007/10/02)

SYNTHESIS OF CINNAMOYLANILINES AND STUDY OF THEIR CHOLAGOGIC ACTIVITY
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Simonyan, E. V.,Vasilenko, Yu. K.,Oganesyan, E. T.,Chomaeva, S. Kh.,Konopleva, G. E.
p. 877 - 879
(2007/10/02)

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Chemical Properties

Boiling Point: 538.1oC at 760 mmHg
Flash Point:279.2oC
Density: 1.31g/cm3
Vapor Pressure: 2.08E-12mmHg at 25°C
PSA: 66.40000
LogP: 3.10970

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