- The crystal structure and conformational studies of acridinedione derivatives
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Two crystal structures of acridinediones namely, TMHAD and MPHAD were studied by X-ray crystallographic method in view of their occurrence in numerous commercial products including pharmaceuticals, fragrances and dyes. Crystal data of TMHAD are: C17H23NO2, orthorhombic, Fdd2, with cell parameters a = 40.417(6) A, b = 5.744(1) A, c = 12.979(2) A, V = 3013.1(7) A3, Z = 8, Dcal = 1.205 Mg/m3, μ = 0.078 mm-1. Crystal data of MPHAD are: C20H18NO3; monoclinic, P21/c with cell parameters a = 10.182(9) A, b = 17.105(14) A, c = 10.895(9) A, β = 117.857(1)°, V = 1678(2) A3, Z = 4, Dcal = 1.268 Mg/m3, μ = 0.085 mm-1. Both data were collected using λ (MoKα) = 0.71073 A. The central ring in the acridinedione moieties tends to be planar while the outer two rings adopt sofa conformations. Intermolecular interactions of C-H...O type of hydrogen bond help the molecules to stabilize into the crystal packing. Interestingly, a week forces of C-H...π interactions also helps the molecules for stabilization. Graphical Abstract: Two crystal structures of acridinediones namely, TMHAD and MPHAD have been synthesized and its structural chemistry has been proved by crystallographic study.
- Natarajan, Sampath,Mathews, Rita
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experimental part
p. 678 - 683
(2011/12/03)
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- Synthesis of tetraketones in water and under catalyst-free conditions
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A simple, environmentally friendly, tandem Knoevenagel condensation and Michael addition procedure is reported. The reactions between cyclic-13-diketones and a variety of aldehydes were carried out in water to afford tetraketones (64-99%). In this green synthetic protocol, the solvent water itself catalysed the reaction by hydrogen bonding, thus avoiding the use of any other catalysts to make the work up procedure easier.
- Yu, Jian-Jun,Wang, Li-Min,Liu, Jin-Qian,Guo, Feng-Lou,Liu, Ying,Jiao, Ning
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scheme or table
p. 216 - 219
(2011/03/19)
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- Thermal and microwave assisted synthesis of N-aroylamino acridinediones
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A series of N-aroylamino acridinediones (3a-3d and 6a-6e) have been synthesized from tetraketones (1 and 4) and benzoic hydrazides (2a-2d and 5a-5e) under thermal and microwave irradiation conditions with solid supports.
- Josephrajan,Ramakrishnan
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p. 572 - 575
(2008/02/12)
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- APOPTOSIS INHIBITORS
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Apoptosis inhibitors containing as the active ingredient compounds represented by general formula (I) or salts thereof, wherein W1 represents -O-, -CH2-, etc.; W2 represents -CH2-, etc.; W3 represents -O-, -CH2-, etc.; X represent CH, C-, etc.; and A represents formula (α) wherein W4 represents -O-, -CH2-, etc.; W5 represents -CH2 -, etc.; and W6 represents -O-, CH2 -, etc. These apoptosis inhibitors inhibit apoptosis of WC8 cells induced by Fas ligand. In animal models, they potently inhibit the progress of fulminant hepatitis and relieve alopecia caused by anticancer agents. Because of being highly safe, these apoptosis inhibitors are usable as beneficial drugs.
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- A New Class of Laser Dyes from Acridinedione Derivatives
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Synthesis of 10-aryl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione as a new class of laser dyes is reported.These dyes lase around 475-495 nm and are compared to the standard dye coumarin 102.
- Shanmugasundaram, Palanisamy,Prabahar, K. Joseph,Ramakrishnan, Vayalakkavoor T.
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p. 1003 - 1008
(2007/10/02)
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