54151-74-5

Basic information

• Product Name: 2-BROMO-4-PHENYLPYRIDINE
• Synonyms: Pyridine, 2-bromo-4-phenyl-;(2-Bromo-pyridin-4-yl)benzene;2-bromo-4-phenyl-pyridin;2-BROMO-4-PHENYLPYRIDINE;4-Phenyl-2-bromopyridine;Methyl 2-bromo-4-phenylpyridine
• CAS NO: 54151-74-5
• Molecular Formula: C₁₁H₈BrN
• Molecular Weight: 234.09
• Mol File: 54151-74-5.mol

Chemical Properties

• Melting Point: 65-66 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 311.7 °C at 760 mmHg
• Flash Point: 142.3 °C
• Appearance: /
• Density: 1.426 g/cm³
• Vapor Pressure: 0.00102mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.96±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-PHENYLPYRIDINE(54151-74-5)
• EPA Substance Registry System: 2-BROMO-4-PHENYLPYRIDINE(54151-74-5)

Safety Data

• Hazardous Substances Data: 54151-74-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-BROMO-4-PHENYLPYRIDINE is used as a key intermediate for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides. Its unique structure allows for the formation of diverse chemical entities with potential therapeutic and pesticidal properties.
Used in Research and Development:
In the realm of research and development, 2-BROMO-4-PHENYLPYRIDINE serves as a building block for the creation of more complex organic compounds. Its structural features facilitate the synthesis of novel molecules with potential applications in various fields, including medicine, chemistry, and materials science.
Used in Materials Science:
2-BROMO-4-PHENYLPYRIDINE finds applications in the field of materials science, where it is utilized to develop new materials with specific properties. Its incorporation into various materials can lead to the enhancement of their performance, such as improved stability, reactivity, or selectivity.
Used as a Reagent in Chemical Reactions:
In chemical reactions, 2-BROMO-4-PHENYLPYRIDINE is employed as a reagent, enabling the transformation of other compounds into desired products. Its reactivity and functional groups make it a useful component in various synthetic routes, facilitating the production of a wide range of chemical entities.

InChI:InChI=1/C11H8BrN/c12-11-8-10(6-7-13-11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 60781-83-1 4-phenyl-pyridin-2-ylamine 
• 58530-53-3 2,4-dibromopyridine 
• 98-80-6 phenylboronic acid 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 100-58-3 phenylmagnesium bromide 
• 14368-40-2 3-phenyl-2-butenonitrile 
• 603-33-8 triphenylbismuthane 
• 42260-39-9 2-chloro-4-(phenyl)pyridine 
• 939-23-1 p-phenylpyridine 
• 109-04-6 2-bromo-pyridine 
• 591-50-4 iodobenzene 

Downstream Products

• 6153-92-0 4,4'-diphenyl-2,2'-bipyridine 
• 18714-16-4 4-phenyl-pyridine-2-carbonitrile 
• 52565-57-8 ethyl 4-phenylpyridine-2-carboxylate 
• 926646-62-0 4-(4-phenylpyridine-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 26274-35-1 2,4-diphenylpyridine 
• 1238944-73-4 N-2-pyridyl(4-phenyl-2-pyridyl)amine 
• 1451006-92-0 (S)-2-(tert-butoxy)-2-(7-(4,4-dimethylpiperidin-1-yl)-5-methyl-2-(4-phenylpyridin-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid 
• 939-23-1 p-phenylpyridine 

Relevant articles and documents

A Dichotomy in Cross-Coupling Site Selectivity in a Dihalogenated Heteroarene: Influence of Mononuclear Pd, Pd Clusters, and Pd Nanoparticles-The Case for Exploiting Pd Catalyst Speciation

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This report describes the synthesis of 4-aryl-2-halopyridines via γ-functionalization of α,β-unsaturated nitriles, which were obtained by the HWE reaction with the corresponding ketones. The key features of our methods involve a conjugated γ-enamine formation of α,β-unsaturated nitrile (enamino nitrile), followed by consecutive intramolecular cyclization, resulting in heteroaromatic compounds like 2-halopyridines, α-pyrone, etc.

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