- Class of large ring heterocyclic compound restraining HCV and manufacturing and uses thereof
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The invention relates to a class of compounds that inhibit HCV. The compounds are represented by Formula A. The invention also relates to preparation and pharmaceutical use of the compounds.
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Paragraph 0291; 0292; 0293; 0295
(2017/09/01)
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- Copper Complexes of New Redox-Active 4,5-Bisguanidino-Substituted Benzodioxole Ligands: Control of the Electronic Structure by Counter-Ligands, Solvent, and Temperature
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Herein, we analyze the possibility of controlling the electronic structure of mononuclear copper complexes featuring new redox-active 4,5-bisguanidino-substituted benzodioxole ligands. The nature of the guanidino groups, the anionic counter-ligands, the applied solvent (polarity), and the temperature are the parameters that decide if a CuIIcomplex with neutral ligand unit or a CuIcomplex with radical monocationic ligand unit is the adequate description. Under special conditions, a temperature-dependent equilibrium of the two valence tautomeric forms (CuII/neutral ligand and CuI/radical monocationic ligand) is achieved. Removal of a ligand-centered electron from a paramagnetic CuIIcomplex with a neutral ligand unit leads to a diamagnetic CuIcomplex with a dicationic ligand unit through a redox-induced electron-transfer (RIET) process.
- Schrempp, David Fridolin,Kaifer, Elisabeth,Wadepohl, Hubert,Himmel, Hans-J?rg
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supporting information
p. 16187 - 16199
(2016/10/30)
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- HETEROCYCLIC HYDRAZIDE DERIVATIVES OF MONOCYCLIC BETA-LACTAM ANTIBIOTICS
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Antibacterial activity has been found in compounds of the formula. Compounds having the formula and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene; Q completes a 5- or 6-membered saturated or unsaturated(including aromatic) heterocyclic ring having one or two, hetero atoms in the ring selected from nitrogen sulfur or oxygen; X is attached to an available carbon atom in the heterocyclic ring and is hydrogen or oxo; Y is attached to an available carbon atom in the heterocyclic ring and is hydrogen, amino, hydroxyl, halogen, carboxamide, nitrile, or carboxyl, except that Y is not carboxyl when the bicyclic ring completed by Q is 2-quinolyl, 3-quinolyl, or quinoxalyl; and the remaining symbols are as defined in the specification
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- Pesticidal heterocyclic compounds
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Compounds of the general formula: wherein R1 represents a hydrogen or halogen atom; R2 represents a halogen atom; R3 represents a hydrogen or halogen atom or an alkyl group; R4 and R5 each independent
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- Imidazole derivatives
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Tricyclic imidazole derivatives of the formula STR1 wherein R1 is 2-pyridyl optionally substituted by lower alkyl or lower alkoxy, n is the integer 0 or 1, R2 is hydrogen or lower alkyl, R3 and R4, independently, are hydrogen or lower alkyl, A is a group of the formula STR2 m is the integer 2 or 3, R5, R6, R7 and R8, independently, are hydrogen or lower alkyl, and R9 is hydrogen and R10 is hydrogen or lower alkyl or R9 and R10 taken together are oxo, provided that at least one of R3 and R4 is lower alkyl when A is a group of the formula and their pharmaceutically acceptable acid addition salts. The compounds of formula I inhibit gastric acid secretion and prevent the formation of gastric ulcers.
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- An Improved Method for the Synthesis of 2,2-disubstituted and 2-Monosubstituted 1,3-Benzodioxoles
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The reactions of catechol with ketones and aldehydes have been studied and convenient procedures have been developed for the preparation of the title compounds in high yields.These products undergo virtually quantitative nitration at position 5, thus providing a source of derivatives substituted in the benzene ring.
- Cole, Edward R.,Crank, George,Minh, H. T. Hai
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p. 675 - 680
(2007/10/02)
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- 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
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3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.
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