- Reactivity of metal-containing monomers 66.* Hydrogenation of nitrotoluene derivatives in the presence of polymer-immobilized Pd nanoparticles
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A new approach to the synthesis of immobilized catalysts of the mixed type was developed: frontal polymerization of metal-containing monomers in the presence of a highly dispersed inorganic support. The synthesis of the acrylamide complex of PdII nitrate on the SiO2 surface followed by polymerization and reduction results in the formation of a polymer-inorganic composite with inclusions of Pd nanoparticles stabilized by the polymer matrix on the support surface. The study of the catalytic properties in the hydrogenation of nitrotoluene derivatives showed that the polymer-immobilized Pd nanoparticles on the inorganic support are efficient catalysts for the reduction of the nitrocompounds.
- Dzhardimalieva,Dorokhov,Golubeva,Pomogailo,Lyakhovich,Savchenko,Pomogailo
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experimental part
p. 2070 - 2076
(2011/01/06)
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- Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid
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Based on the promising activity of an indole-3-carboxamide derivative, a nonphenolic analog of mycophenolic acid (MPA), we report herein the synthesis of a compound containing two important features for the activity of MPA, the ring methoxy and methyl. The synthesis was accomplished using two strategies; a method dependent on stepwise building of the hexenoate side chain followed by the indolecarboxamide ring system, and a convergent route that depended on 1,3-sigmatropic rearrangement as a key step. Docking experiments on both Chinese Hamster and Human Type-II inosine monophosphate dehydrogenase (IMPDH) showed that this compound has potential binding interactions with the NAD site. The analogs showed no activity against MCF7-S, MCF7-R, or IGR-OV1 cancer cells.
- El-Araby, Moustafa E.,Bernacki, Ralph J.,Makara, Gergely M.,Pera, Paula J.,Anderson, Wayne K.
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p. 2867 - 2879
(2007/10/03)
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- Transition metal complexes in organic synthesis. Part 33. Molybdenum-mediated total synthesis of girinimbine, murrayacine, and dihydroxygirinimbine
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A highly convergent total synthesis of the pyrano[3,2-a]carbazole alkaloids girinimbine, murrayacine, and dihydroxygirinimbine has been accomplished using a consecutive molybdenum-mediated C-C- and C-N-bond formation.
- Knoelker, Hans-Joachim,Hofmann, Christoph
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p. 7947 - 7950
(2007/10/03)
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- Pesticidal 3-arylpyrimidinyl ethers and thioethers
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This invention is related to a novel class of 3-arylpyrimidine ethers and thioethers having insecticidal, miticidal and nematocidal activity at low concentration. The class of compounds is represented by formula (I): STR1 wherein R1, R2, R3, R4, R5, R6, R7, X and Y have the significance given in the description. Pesticidal compositions, methods of controlling pests and methods for preparing the compounds are within the scope of the invention.
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- Electron Rich Heterocycles as Donor Groups in Fluorescent Dyes
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The synthesis of N-methylphthalimides substituted with the donor groups pyrazole, triazole, benzotriazole, and naphthotriazole in position 4 is described (17, 18, 14, 12).The substituent constants of these groups are obtained by alkaline hydrolysis of the corresponding phthalimide dyes.Their solvatochromism in absorption and fluorescence gives information about charge distribution in ground- and excited state.
- Fritzsche, Katharina,Langhals, Heinz
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p. 2275 - 2286
(2007/10/02)
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