2486-63-7Relevant articles and documents
Novel preparation method of mosapride
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, (2021/08/07)
The invention discloses a novel preparation method of mosapride.Cheap 2-chlorotoluene is used as an initial raw material is subjected to nitration, nucleophilic substitution, free radical bromination, chlorination, alkylation, nitro reduction and oxidative amidation to synthesize mosapride. According to the scheme, raw materials are easy to obtain, dangerous processes and highly toxic reagents are avoided, the method is green and environment-friendly, oxidation amidation is adopted, selectivity is achieved, formation of aromatic amide by-products is avoided, and the yield is high.
Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: Relationship between absolute configuration and subtype selectivity
Motoshima, Kazunori,Ishikawa, Minoru,Hashimoto, Yuichi,Sugita, Kazuyuki
experimental part, p. 3156 - 3172 (2011/06/26)
Introduction of an alkylcarboxylic acid unit, which is a partial structure of endogenous peroxisome proliferator-activated receptor (PPAR) ligands, into a phenethylphenylphthalimide skeleton, which possesses liver X receptor (LXR) antagonistic activity, afforded novel PPAR ligands. The results of structure-activity relationship analysis and docking studies led us to the potent PPAR agonists 13c-e. The absolute configuration of 13c-e affects the PPAR subtype selectivity.
IMIDAZOLIDINEDIONE DERIVATIVES
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Page/Page column 74, (2011/06/26)
The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.