- Cyclometalated rhodium(III) complexes bearing dithiocarbamate derivative: Synthesis, characterization, interaction with DNA and biological study
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Reaction of three different dithiocarbamates (4-MePipzcdtH, L1H; MorphcdtH, L2H and 4-BzPipercdtH, L3H) with [Rh(2-C 6H4py)2Cl]2.1/4CH2Cl 2 afforded a class
- Mukherjee, Titas,Sen, Buddhadeb,Patra, Animesh,Banerjee, Snehasis,Hundal, Geeta,Chattopadhyay, Pabitra
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p. 127 - 134
(2014/01/06)
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- Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates
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A series of 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl) propyl dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal activities were evaluated. Among these compounds, 2a-f and 3a-q exhibited higher activities than fluconazole against nearly all fungi tested except Aspergillus fumigatus. Noticeably, the in vitro biological activities of 2b, 3a, 3c, 3h-k, and 3o-q against Candida species were much better than those of fluconazole and ketoconazole. Also, 2a-d, 3a-d, 3e-f, 3h-k, 3p and 3q showed higher activities against A. fumi than fluconazole. Computational docking experiments indicated that the inhibition of CYP51 involved a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft.
- Zou, Yan,Yu, Shichong,Li, Renwu,Zhao, Qingjie,Li, Xiang,Wu, Maocheng,Huang, Ting,Chai, Xiaoxun,Hu, Honggang,Wu, Qiuye
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p. 366 - 374
(2014/02/14)
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- Synthesis, characterization, interactions with DNA and bovine serum albumin (BSA), and antibacterial activity of cyclometalated iridium(III) complexes containing dithiocarbamate derivatives
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Three mononuclear cyclometalated iridium(III) complexes having dithiocarbamate ligands, [IrIII(2-C6H4py)2(L)] (where 2-C6H4py = 2-phenylpyridine; and L1H = 4-MePipzcdtH, L2
- Mukherjee, Titas,Mukherjee, Manjira,Sen, Buddhadeb,Banerjee, Snehasis,Hundal, Geeta,Chattopadhyay, Pabitra
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p. 2643 - 2660
(2015/10/20)
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- Synthesis and cytotoxicity screening of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones
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A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung ca
- Cao, Sheng-Li,Guo, Yan-Wen,Wang, Xian-Bo,Zhang, Mei,Feng, Yu-Ping,Jiang, Yu-Yang,Wang, Yue,Gao, Qian,Ren, Jian
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experimental part
p. 182 - 189
(2009/05/26)
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