5430-77-3

Usage

Organosulfur compound

Contains both piperazine and carbodithioic acid moieties

Synthesis

Used in the synthesis of various pharmaceuticals and agrochemicals

Potential properties

Studied for its potential anti-tumor and anti-cancer properties

Hazards

Potential hazards, should be handled with caution and under the guidance of a qualified professional.

InChI:InChI=1/C6H12N2S2/c1-7-2-4-8(5-3-7)6(9)10/h2-5H2,1H3,(H,9,10)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 75-15-0 carbon disulfide 
• 3074-43-9 1-methyl-4-phenylpiperazine 
• 55-86-7 mechlorethamine hydrochloride 

Downstream Products

• 101266-25-5 benzyl 4-methylpiperazine-1-carbodithioate 
• 98428-90-1 4-methyl-piperazine-1-carbodithioic acid methyl ester 
• 1158187-72-4 (2-benzyl-3,4-dihydro-4-oxoquinazolin-6-yl)methyl 4-methylpiperazine-1-carbodithioate 
• 1158187-76-8 (3,4-dihydro-4-oxo-2-phenylquinazolin-6-yl)methyl 4-methylpiperazine-1-carbodithioate 
• 1218949-08-6 [Pd(N-methylpiperazinedithiocarbamate)(tri-o-tolylphosphine)Cl] 
• 1218949-09-7 [Pd(N-methylpiperazinedithiocarbamate)(diphenylchlorophosphine)Cl] 
• 1218949-07-5 [Pd(N-methylpiperazinedithiocarbamate)(triphenylphosphine)Cl] 
• 109-01-3 1-methyl-piperazine 
• 75-15-0 carbon disulfide 

Relevant academic research and scientific papers

Cyclometalated rhodium(III) complexes bearing dithiocarbamate derivative: Synthesis, characterization, interaction with DNA and biological study

Reaction of three different dithiocarbamates (4-MePipzcdtH, L1H; MorphcdtH, L2H and 4-BzPipercdtH, L3H) with [Rh(2-C 6H4py)2Cl]2.1/4CH2Cl 2 afforded a class

Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates

A series of 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl) propyl dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal activities were evaluated. Among these compounds, 2a-f and 3a-q exhibited higher activities than fluconazole against nearly all fungi tested except Aspergillus fumigatus. Noticeably, the in vitro biological activities of 2b, 3a, 3c, 3h-k, and 3o-q against Candida species were much better than those of fluconazole and ketoconazole. Also, 2a-d, 3a-d, 3e-f, 3h-k, 3p and 3q showed higher activities against A. fumi than fluconazole. Computational docking experiments indicated that the inhibition of CYP51 involved a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft.

Synthesis, characterization, interactions with DNA and bovine serum albumin (BSA), and antibacterial activity of cyclometalated iridium(III) complexes containing dithiocarbamate derivatives

Three mononuclear cyclometalated iridium(III) complexes having dithiocarbamate ligands, [IrIII(2-C6H4py)2(L)] (where 2-C6H4py = 2-phenylpyridine; and L1H = 4-MePipzcdtH, L2

Synthesis and cytotoxicity screening of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones

A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung ca