- Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids
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A versatile method for orchestrating the formation of side chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Upon ribosomal incorporation into intein-containing precursor proteins, designer unnatural amino acids be
- Frost, John R.,Jacob, Nicholas T.,Papa, Louis J.,Owens, Andrew E.,Fasan, Rudi
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p. 1805 - 1816
(2015/09/01)
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- MACROCYCLIC PEPTIDOMIMETICS FOR ALPHA-HELIX MIMICRY
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Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and structural mimics of α-helical motifs, including in therapeutic applications. These methods can be used to produce libraries of conformationally constrained peptidomimetics to identify compounds with desired activity properties.
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Paragraph 00255
(2015/11/02)
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- Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase
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The present invention relates to the use of 2-aminothiazoline derivatives of formula: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, —CH2—R3, —CH2—S
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- Streptogramins for preparing same by mutasynthesis
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The invention provides a method for preparing streptogramins using genetically-modified microorganisms to influence the biosynthesis of at least one of the precursors of the group B streptogramins. Cultures of the genetically-modified microorganisms are supplemented with a least one precursor that is different from the streptogramin precursor whose biosynthesis is altered and the streptogramins produced are recovered.
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- Gonadotropin-Releasing Hormone Antagonists: Novel Members of the Azaline B Family
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A series of antagonists of gonadotropin-releasing hormone (GnRH) homologous to azaline B (1, DCpa2, DPal3, Aph5(Atz), DAph6(Atz), ILys8, DAla10>GnRH) was synthesized, cha
- Rivier, Jean E.,Jiang, Guangcheng,Porter, John,Hoeger, Carl A.,Craig, A. Grey,et al.
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p. 2649 - 2662
(2007/10/03)
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