5432-19-9Relevant academic research and scientific papers
Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids
Frost, John R.,Jacob, Nicholas T.,Papa, Louis J.,Owens, Andrew E.,Fasan, Rudi
, p. 1805 - 1816 (2015/09/01)
A versatile method for orchestrating the formation of side chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Upon ribosomal incorporation into intein-containing precursor proteins, designer unnatural amino acids be
MACROCYCLIC PEPTIDOMIMETICS FOR ALPHA-HELIX MIMICRY
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Paragraph 00255, (2015/11/02)
Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and structural mimics of α-helical motifs, including in therapeutic applications. These methods can be used to produce libraries of conformationally constrained peptidomimetics to identify compounds with desired activity properties.
Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase
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, (2008/06/13)
The present invention relates to the use of 2-aminothiazoline derivatives of formula: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, —CH2—R3, —CH2—S
Streptogramins for preparing same by mutasynthesis
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, (2008/06/13)
The invention provides a method for preparing streptogramins using genetically-modified microorganisms to influence the biosynthesis of at least one of the precursors of the group B streptogramins. Cultures of the genetically-modified microorganisms are supplemented with a least one precursor that is different from the streptogramin precursor whose biosynthesis is altered and the streptogramins produced are recovered.
Gonadotropin-Releasing Hormone Antagonists: Novel Members of the Azaline B Family
Rivier, Jean E.,Jiang, Guangcheng,Porter, John,Hoeger, Carl A.,Craig, A. Grey,et al.
, p. 2649 - 2662 (2007/10/03)
A series of antagonists of gonadotropin-releasing hormone (GnRH) homologous to azaline B (1, DCpa2, DPal3, Aph5(Atz), DAph6(Atz), ILys8, DAla10>GnRH) was synthesized, cha
