Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II
Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are de
Bruno, Claudio,Lentini, Giovanni,Catalano, Alessia,Carocci, Alessia,Lovece, Angelo,Di Mola, Antonia,Cavalluzzi, Maria Maddalena,Tortorella, Paolo,Loiodice, Fulvio,Iaccarino, Guido,Campiglia, Pietro,Novellino, Ettore,Franchini, Carlo
experimental part
p. 4193 - 4198
(2011/02/22)
POTENTIAL CNS ACTIVE 1-ARYL-2-AMINO-1-ETHANOL DERIVATIVES
New N-(picolyl)-2-(methylamino)-1-aryl-1-ethanols (I) and their O-acyl derivatives (II) were synthesized.Their dopaminomimetic and antidepressant biological activities were examined and compared with the activities of N-(2-aminobenzyl)-2-(methylamino)-1-aryl-1-ethanols (III).It was established that in the reaction of N- methylamine (2) and styryl oxide, the two directions of the splitting of the epoxide ring give rise to two different products that were isolated and identified in the form of their O-acetyl derivatives (13 and 15, respectively).
Zara-Kaczian, Erzsebet,Deak, Gyula,Gyoergy, Lajos
p. 441 - 454
(2007/10/02)
A Convenient Preparation of 3-Methyl-3,4-dihydro-2(1H)-quinazolinone
3-Methyl-3,4-dihydro-2(1H)-quinazolinone (5) can be prepared in good yield and quality from o-nitrobenzyl chloride (1).The three-step sequence requires no purification of intermediates or final product.
Golec, Frederick A.,Reilly, Laurence W.
p. 789 - 790
(2007/10/02)
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