- Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII
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Coumarins are widely diffused secondary metabolites possessing a plethora of biological activities. It has been established that coumarins represent a peculiar class of human carbonic anhydrase (hCA) inhibitors having a distinct mechanism of action involv
- Angeli, Andrea,Capasso, Clemente,De Luca, Laura,Del Prete, Sonia,Gitto, Rosaria,Mancuso, Francesca,Supuran, Claudiu T.
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p. 1442 - 1449
(2020/07/13)
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- Synthesis and biological activity of meso-tetrakis (2,10-dioxo-2H, 10H-pyrano [2,3-f] chromene-9-yl) porphyrins
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Synthesis of meso-tetrakis (2, 10-dioxo-2H, 10H-pyrano[2,3-f] chromene-9-yl) porphyrins are synthesized directly by reaction of pyrrole with substituted 4-methyl-2,10-dioxo-2H, 10H-pyrano[2,3-f]chromene-9-carbaldehydes in dichloromethane / acid media. The aldehyde's molar ratio was controlled to optimize the synthesis and purification of the desired porphyrins. This new series of porphyrins was characterized by TLC, Mass Spectrometry (FAB mass), 1H NMR, UV and IR ARKAT.
- Kumar, V. Naveen,Thirupathi Reddy,Narasimhareddy,Rajitha,De Clercq
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p. 181 - 188
(2013/09/12)
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- Photo-induced Reactions: Part IV-Studies on Photo Fries Migration of Some Coumarins
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Photo-Fries migration as an alternative route to acylcoumarins has been investigated. 7-Acetoxy- and 7-furoyloxy-coumarins give 6-acylcoumarins as the major products in contrast to Lewis acid mediated Fries migration where 8-acyl derivatives are the major products.The benzoates on the other hand give 6- and 8-acylcoumarins in equal proportions.The method is not suitable for the preparation of long chain unsaturated acyl derivatives of coumarins because in such cases photolytic deesterification is the main route.
- Kulshrestha, S.K.,Dureja, P.,Mukerjee, S.K.
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p. 1064 - 1067
(2007/10/02)
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