545410-47-7

Basic information

• Product Name: 2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE
• Synonyms: 1-(2,5-Bis(trifluoroMethyl)phenyl)ethanone;1-(2,5-Bis(trifluoromethyl)
• CAS NO: 545410-47-7
• Molecular Formula: C₁₀H₆F₆O
• Molecular Weight: 256.144
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 545410-47-7.mol

Chemical Properties

• Boiling Point: 206.1 °C at 760 mmHg
• Flash Point: 76.9 °C
• Appearance: /
• Density: 1.362 g/cm³
• Refractive Index: 1.4200
• Water Solubility: Sparingly soluble in water.
• CAS DataBase Reference: 2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE(545410-47-7)
• EPA Substance Registry System: 2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE(545410-47-7)

Safety Data

• Hazardous Substances Data: 545410-47-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE is used as a key intermediate in the synthesis of monoamine oxidase-B (MAO-B) inhibitors. These inhibitors play a crucial role in the treatment of various neurological and psychiatric disorders, such as Parkinson's disease and depression, by regulating the levels of monoamines in the brain.
Used in Microbiology Research:
In the field of microbiology, 2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE is utilized for the isolation of novel bacterial strains from soil samples. 2,5-bis(TRIFLUOROMETHYL)ACETOPHENONE's unique chemical properties enable the selective growth and identification of specific bacterial species, contributing to the discovery of new microorganisms with potential applications in biotechnology, agriculture, and environmental science.

Upstream product

• 393-82-8 2,5-bis(trifluoromethyl)benzoyl chloride 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 545410-49-9 2-bromo-1-[(2,5-bis-trifluoromethyl)phenyl]-ethanone 
• 545410-53-5 1-(2,5-Bistrifluoromethylphenyl)-2-(imidazol-1-yl)ethanol 
• 545410-51-3 2,5-bistrifluoromethyl-1-(imidazol-1-ylmethylcarbonyl)benzene 
• 545410-54-6 1-(2,5-bistrifluoromethylphenyl)-2-(imidazol-1-yl)ethylamine 

Relevant articles and documents

(1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase

Compounds having the formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F1F0 ATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, and cardiac arrhythmias.

N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase

A series of substituted guanidine derivatives were prepared and evaluated as potent and selective inhibitors of mitochondrial F1F0 ATP hydrolase. The initial thiourethane derived lead molecules possessed intriguing in vitro pharmacological profiles, though contained moieties considered non-drug-like. Analogue synthesis efforts led to compounds with maintained potency and superior physical properties. Small molecules in this series which potently and selectivity inhibit ATP hydrolase and not ATP synthase may have utility as cardioprotective agents.