Cobalt-Catalyzed Reductive Alkylation of Amines with Carboxylic Acids
Direct reductive alkylation of amines with carboxylic acid is carried out by using an inexpensive, air-stable cobalt/triphos catalytic system with molecular hydrogen as the reductant. This efficient synthetic method proceeds through reduction and condensation, followed by reduction of the in situ-generated imine into the amine in a green catalytic process.
Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: Synthesis of secondary amines
Selective ruthenium-catalyzed reductive coupling of primary amides under hydrosilylation conditions is achieved using an one pot procedure. Using 3 equiv. of phenylsilane and [RuCl2(mesitylene)]2 (1-2 mol%) as the catalyst at 100 °C under neat conditions, secondary symmetric amines were obtained in good yields and with high chemoselectivities. The Royal Society of Chemistry 2013.
Li, Bin,Sortais, Jean-Baptiste,Darcel, Christophe
supporting information
p. 3691 - 3693
(2013/05/21)
C-N bond formation catalysed by CuI Bonded to polyaniline nanofiber
Polyaniline nanofiber as a macroligand for the supported cuprous iodide catalyst (CuI-PANInf) has been developed for the coupling of aryl halides (including aryl chlorides) with aliphatic, aromatic, and N(H)-heterocyclic amines under ambient conditions (80 °C for aryl chlorides) has been developed. This simple and efficient method for coupling reactions is highly versatile, convenient, and also the catalyst can be used for several cycles with good-to-excellent yields.
Carbene adduct of cyclopalladated ferrocenylimine as an efficient catalyst for the amination of aryl chlorides
A novel air- and moisture-stable carbene adduct of cyclopalladated ferrocenylimine has been synthesized and characterized. The structure of this compound was determined by X-ray crystal structure analysis. This adduct has been applied as an efficient catalyst for the amination of aryl chlorides.
Li, Jingya,Cui, Mengjun,Yu, Ajuan,Wu, Yangjie
p. 3732 - 3742
(2008/02/08)
Iminomalonate as a convenient electrophilic amination reagent for grignard reagents
Diethyl 2-[N-(p-methoxyphenyl)imino]malonate underwent amination reactions with alkyl Grignard reagents to give N-aklylation products in good yields. The obtained N-alkylation products were readily converted into N-alkyl-panisidines by the oxidative removal of the malonate moiety. The p-methoxyphenyl group was subsequently deprotected to give primary amines.
Niwa, Yasuki,Takayama, Kazuki,Shimizu, Makoto
p. 1819 - 1825
(2007/10/03)
Electrophilic amination with iminomalonate
Diethyl N-anisyliminomalonate has been found to be an excellent electrophilic amination reagent for Grignard reagents to give N-alkylated products in good yields, and subsequent air oxidation affords N-alkylanisidines.
Niwa, Yasuki,Takayama, Kazuki,Shimizu, Makoto
p. 5473 - 5476
(2007/10/03)
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