- NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
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Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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Page/Page column 66
(2010/04/23)
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- COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
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Disclosed herein are cannabinoid receptor ligands of formula (1) wherein Ring A and R1 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also described
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Page/Page column 28
(2010/10/19)
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- Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues
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Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′- didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxys
- Sastraruji, Kwankamol,Sastraruji, Thanapat,Pyne, Stephen G.,Ung, Alison T.,Jatisatienr, Araya,Lie, Wilford
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supporting information; experimental part
p. 935 - 941
(2010/09/05)
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- Compound having polymethine-chain structure, image forming material, planographic printing plate precursor, and image forming method using the same, method of making planographic printing plate, and planographic printing method
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A compound having, in its molecule, a polymethine chain structure containing a partial structure represented by the following formula (1-1), and an image forming material containing the same. In the formula (1-1), R1, R2, R3/su
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Page/Page column 77-78
(2010/11/28)
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- New FBPase inhibitors for diabetes
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Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.
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Page/Page column 19
(2008/06/13)
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- Enantioselective synthesis of cyclic ethers through a vanadium-catalyzed resolution/oxidative cyclization
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(Chemical Equation Presented) Two steps, one catalyst: A vanadium(v)-oxo complex with a tridentate Schiff base as an additional ligand catalyzes the title reaction which transforms racemic bishomoallylic α-hydroxyesters into trans-tetrahydropyrans (THPs)
- Blanc, Aurelien,Toste, F. Dean
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p. 2096 - 2099
(2007/10/03)
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- 4-PHENYLPIPERIDINE DERIVATIVES AS RENIN INHIBITORS
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Compounds of the present invention having the formula (I) exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
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Page/Page column 62-63
(2008/06/13)
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- Reactivity of Neopentyl-Like Compounds in the Synthesis of Branched Polyethers
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Two singly branched symmetrical hexaethers have been synthesized, starting from 2-bromomethyl-2-methyl-1,3-dibromopropane, in a surprisingly efficient one-pot nucleophilic substitution reaction.It is proposed that the expected adverse neopentyl effect is compensated by favourable neighbouring-group participation involving a 'bromonium'-like four-membered-ring transition state.The corresponding trichloride also reacted cleanly, although much more slowly, while the tritosylate gave an oxetane derivative.
- Dale, Johannes,Fredriksen, Siw B.
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p. 278 - 282
(2007/10/02)
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