548772-42-5

Basic information

• Product Name: 2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE
• Synonyms: 2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE;2-(5-Chlorothiophenyl-2-yl)ethanamine hydrochloride;2-(5-Chloro-thiophen-2-yl)-ethylamine hydrochloride
• CAS NO: 548772-42-5
• Molecular Formula: C6H9Cl2NS
• Molecular Weight: 198.11
• Mol File: 548772-42-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE(548772-42-5)
• EPA Substance Registry System: 2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE(548772-42-5)

Safety Data

• Hazardous Substances Data: 548772-42-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE is used as a building block for the synthesis of various pharmaceuticals due to its amine group and thiophene derivative structure.
Used in Drug Development for Neurological Disorders:
2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE is used as a potential drug candidate for the treatment of neurological disorders, given its potential pharmacological significance.
Used in Drug Development for Psychiatric Conditions:
2-(5-CHLOROTHIOPHEN-2-YL)ETHANAMINE HYDROCHLORIDE is used as a potential drug candidate for the treatment of psychiatric conditions, given its potential pharmacological significance.

Upstream product

• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 381666-12-2 tert-butyl (2-(thiophen-2-yl)ethyl)carbamate 

Relevant articles and documents

Regiospecific synthesis of 5-halo-substituted thiophene pyridyl thiourea compounds as non-nucleoside inhibitors of HIV-1 reverse transcriptase

The regiospecific synthesis of 5-halothiophenethylamines and halo-substituted phenylethyl thioureas was accomplished with an overall yield of 45-60%. Condensation of t-boc protected 2-thiophenethylamine with N-halo succinamide in dimethylformamide furnished the desired halo-substituted thiophenethylamines. These thiophenethyl amines were further converted into biologically active thiourea compounds using thiocarbonyldiimidazole chemistry. Several of the halo-substituted thiophene pyridyl thiourea compounds inhibited HIV-1 reverse transcriptase (RT) at nanomolar concentrations.

Mono-chlorination of electron-rich arylalkyl- and heteroarylalkyl-amines and amino acids using sulfuryl chloride

Sulfuryl chloride has been used to mono-chlorinate electron-rich arylalkyl- and heteroarylalkyl-amines and amino acids in a mild and efficient one-pot transformation with straightforward purification. Protection of the amines was not needed, and racemization of the chiral amino acids was minimal.