548785-17-7Relevant articles and documents
Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy
Li, Jin,Wu, Yuelin,Guo, Zizhao,Zhuang, Chunlin,Yao, Jianzhong,Dong, Guoqiang,Yu, Zhiliang,Min, Xiao,Wang, Shengzheng,Liu, Yang,Wu, Shanchao,Zhu, Shiping,Sheng, Chunquan,Miao, Zhenyuan,Zhang, Wannian
supporting information, p. 2648 - 2650 (2014/06/09)
Introducing an aryl moiety to our previous pyrrolidone scaffold by molecule fusing strategy afforded two sets of isopropylether-pyrrolidone and α-phenylethylamine-pyrrolidone derivatives. Two novel compounds 8b and 8g of the latter serial showed potent p5
Cis-imidazolines
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, (2008/06/13)
The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity