778-94-9Relevant articles and documents
Conversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions
Cai, Hu,Cao, Xihan,Fu, Zhengjiang,Guo, Shengmei,Wang, Shuiliang
supporting information, p. 8381 - 8385 (2020/11/05)
Here, we used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols. This journal is
Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids with K4Fe(CN)6 under aerobic conditions
Fu, Zhengjiang,Jiang, Ligao,Li, Zhaojie,Jiang, Yongqing,Cai, Hu
supporting information, p. 917 - 924 (2019/03/17)
A method for facile synthesis of aryl nitriles has been well established via Ag/Cu-mediated decarboxylative cyanation of benzoic acids with K4Fe(CN)6 under aerobic conditions. The approach of using readily accessible aryl carboxylic acids and green K4Fe(CN)6 as starting material provides a feasible alternative to previous cyanation protocols. Control experiments revealed the key role of Cu for the process and excluded the possibility of a radical mechanism for the transformation.
Synthesis method of p-trifluoromethyl benzonitrile compound
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Paragraph 0047-0051; 0054-0067, (2019/10/02)
The invention relates to a preparation method of a p-trifluoromethyl benzonitrile compound. The structural formula of the p-trifluoromethyl benzonitrile compound is shown as formula (I), wherein X isa group selected from nitro or halogen. The p-trifluoromethyl benzonitrile compound is prepared by reacting a compound shown as formula (II) with cuprous cyanide under the action of sodium bromide or/and potassium bromide. The method provided by the invention adopts a low-cost catalyst, has a reaction conversion rate and selectivity up to 95% or more, also makes inorganic salts and tar easy to separate in the subsequent treatment process, thereby simplifying the post-treatment process and reducing the discharge of three wastes, and the method is suitable for large-scale industrial production.