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2-Chloro-6-methylnicotinamide, a chemical compound with the molecular formula C7H7ClN2O, is a derivative of nicotinamide featuring a chlorine atom and a methyl group attached to a pyridine ring. It is recognized for its unique structure and properties, making it a valuable precursor in the synthesis of pharmaceuticals and bioactive molecules.

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  • 54957-84-5 Structure
  • Basic information

    1. Product Name: 2-CHLORO-6-METHYLNICOTINAMIDE
    2. Synonyms: BUTTPARK 153\57-13;2-CHLORO-6-METHYLNICOTINAMIDE;2-Chloro-6-methylincotinamide;2-Chloro-6-methylnicotinamide, 95+%;2-CHLORO-6-METHYLPYRIDINE-3-CARBOXAMIDE
    3. CAS NO:54957-84-5
    4. Molecular Formula: C7H7ClN2O
    5. Molecular Weight: 170.6
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 54957-84-5.mol
  • Chemical Properties

    1. Melting Point: 179 °C
    2. Boiling Point: 285.2°C at 760 mmHg
    3. Flash Point: 126.3°C
    4. Appearance: /
    5. Density: 1.316g/cm3
    6. Vapor Pressure: 0.00284mmHg at 25°C
    7. Refractive Index: 1.577
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-CHLORO-6-METHYLNICOTINAMIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-CHLORO-6-METHYLNICOTINAMIDE(54957-84-5)
    12. EPA Substance Registry System: 2-CHLORO-6-METHYLNICOTINAMIDE(54957-84-5)
  • Safety Data

    1. Hazard Codes:  Xi:Irritant;
    2. Statements: 36/37/38
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 54957-84-5(Hazardous Substances Data)

54957-84-5 Usage

Uses

Used in Organic Synthesis:
2-Chloro-6-methylnicotinamide is used as a building block in organic synthesis for the creation of various pharmaceuticals. Its distinctive chemical structure allows for the development of new compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Chloro-6-methylnicotinamide is utilized as a key intermediate for the synthesis of drugs. Its presence in the molecular structure can influence the pharmacological properties of the final product, contributing to the discovery of novel therapeutic agents.
Used in Pharmaceutical Development:
2-Chloro-6-methylnicotinamide is employed as a precursor in the development of new drugs. Its chemical versatility facilitates the design and synthesis of molecules with specific biological activities, enhancing the range of available treatments for various diseases.
Used in Anti-inflammatory Applications:
2-Chloro-6-methylnicotinamide has been studied for its potential anti-inflammatory activities. It is used as a therapeutic agent to modulate inflammatory responses, offering a possible treatment for conditions characterized by excessive inflammation.
Used in Antitumor Applications:
2-CHLORO-6-METHYLNICOTINAMIDE has also demonstrated potential antitumor activities, making it a candidate for use as an anticancer agent. It is utilized in research and development to explore its effects on tumor growth and progression, with the aim of identifying new cancer therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 54957-84-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,9,5 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 54957-84:
(7*5)+(6*4)+(5*9)+(4*5)+(3*7)+(2*8)+(1*4)=165
165 % 10 = 5
So 54957-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H7ClN2O/c1-4-2-3-5(7(9)11)6(8)10-4/h2-3H,1H3,(H2,9,11)

54957-84-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-6-methylpyridine-3-carboxamide

1.2 Other means of identification

Product number -
Other names 2-chloro-6-methylnicotinamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54957-84-5 SDS

54957-84-5Relevant articles and documents

2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

-

Page/Page column 99; 100, (2020/05/28)

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

2-Phenyl-3H-imidazopyridine-3-acetamides as Non-Benzodiazepine Anticonvulsants and Anxiolytics

Tomczuk, Bruce E.,Taylor, C. R,Moses, L. Meredith,Sutherland, Deborah B.,Lo, Young S.,et al.

, p. 2993 - 3006 (2007/10/02)

A series of 2-phenyl-3H-imidazopyridine-3-acetamides were designed and synthesized as non-benzodiazepine anxiolytics based on a molecular disconnection of a typical 1,4-benzodiazepine (BZD).A number of these compounds showed submicromolar potency i

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