- 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
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Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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Page/Page column 99; 100
(2020/05/28)
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- 2-Phenyl-3H-imidazopyridine-3-acetamides as Non-Benzodiazepine Anticonvulsants and Anxiolytics
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A series of 2-phenyl-3H-imidazopyridine-3-acetamides were designed and synthesized as non-benzodiazepine anxiolytics based on a molecular disconnection of a typical 1,4-benzodiazepine (BZD).A number of these compounds showed submicromolar potency i
- Tomczuk, Bruce E.,Taylor, C. R,Moses, L. Meredith,Sutherland, Deborah B.,Lo, Young S.,et al.
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p. 2993 - 3006
(2007/10/02)
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