2-Chloro-6-methylnicotinamide

Base Information

• Chemical Name: 2-Chloro-6-methylnicotinamide
• CAS No.: 54957-84-5
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.598
• Hs Code.: 2933399090
• European Community (EC) Number: 829-894-8
• DSSTox Substance ID: DTXSID30384087
• Wikidata: Q82176011
• Mol file: 54957-84-5.mol

Synonyms:2-chloro-6-methylnicotinamide;54957-84-5;2-chloro-6-methylpyridine-3-carboxamide;2-Chloro-6-methylincotinamide;6-methyl-2-chloronicotinamide;SCHEMBL5190356;DTXSID30384087;BBL028336;MFCD00173783;STL316523;AKOS006228432;BP-10707;VS-08723;CS-0308231;FT-0611879;EN300-111818;Z458889072;METHYL9-[METHYL-4-(TRIFLUOROMETHOXY)ANILINO]-9-OXONONANOATE

Chemical Property of 2-Chloro-6-methylnicotinamide

Chemical Property:

• Vapor Pressure: 0.00284mmHg at 25°C
• Melting Point: 179 °C
• Boiling Point: 285.2°C at 760 mmHg
• Flash Point: 126.3°C
• PSA: 55.98000
• Density: 1.316g/cm³
• LogP: 1.84260
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

98%Min ^*data from raw suppliers

2-Chloro-6-methylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi:Irritant
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1)C(=O)N)Cl

Technology Process of 2-Chloro-6-methylnicotinamide

There total 4 articles about 2-Chloro-6-methylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-methyl nicotinic acid (30529-70-5) → 2-chloro-6-methyl-3-pyridinecarboxamide (54957-84-5)

Guidance literature:

2-chloro-6-methyl nicotinic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h;

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

2-chloro-6-methyl-nicotinic acid chloride (39853-81-1) → 2-chloro-6-methyl-3-pyridinecarboxamide (54957-84-5)

Guidance literature:

With ammonium hydroxide; In chloroform; at 0 ℃; Yield given;

DOI:10.1021/jm00114a007

Reference yield:

2-hydroxy-6-methylnicotinic acid (38116-61-9) → 2-chloro-6-methyl-3-pyridinecarboxamide (54957-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃, PCl₅ / 3 h / Heating

2: conc. ammonium hydroxide / CHCl₃ / 0 °C

With ammonium hydroxide; phosphorus pentachloride; trichlorophosphate; In chloroform;

DOI:10.1021/jm00114a007

upstream raw materials:

2-chloro-6-methyl-nicotinic acid chloride

2-hydroxy-6-methylnicotinic acid

2-chloro-6-methyl nicotinic acid

Downstream raw materials:

2-anilino-6-methylnicotinic acid amide

2-chloro-6-methyl-3-aminopyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 54957-84-5 2-CHLORO-6-METHYLNICOTINAMIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send