- HETEROCYCLIC COMPOUNDS AND USES THEREOF
-
Heterocyclic compounds as Weel inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
- -
-
-
- Investigation of biaryl heterocycles as inhibitors of Wee1 kinase
-
In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure?activ
- Mastracchio, Anthony,Lai, Chunqiu,Torrent, Maricel,Bromberg, Kenneth,Buchanan, Fritz G.,Ferguson, Debra,Bontcheva, Velitchka,Johnson, Eric F.,Lasko, Loren,Maag, David,Soni, Nirupama,Shoemaker, Alexander R.,Penning, Thomas D.
-
p. 1481 - 1486
(2019/04/25)
-
- HETEROCYCLIC COMPOUNDS AND USES THEREOF
-
Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
- -
-
-
- Pyrimido-diazepines derivative and medical application thereof
-
The invention relates to a pyrimido-diazepines derivative as shown in formula (I) and pharmaceutically acceptable salt, prodrugs and pharmaceutical compositions. The pyrimido-diazepines derivative is a benzodiazepines receptor antagonist. In the formula, R is methyl, ethyl, trifluoromethyl, cyclopropyl, isopropyl and benzyl, and X is hydrogen or chlorine. The invention also discloses preparation of the pyrimido-diazepines derivative and application of the pyrimido-diazepines derivative as drugs. The formula (I) is as shown in the description.
- -
-
Paragraph 0026-0027
(2017/11/18)
-
- HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
-
The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
- -
-
Paragraph 00618
(2015/05/06)
-
- Substituted Tricyclic Pyrazolo-Pyrimidine Compounds
-
The present invention relates to substituted tricyclic pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tricyclic pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
- -
-
-
- Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
-
This invention is directed to compound of the following formula (I): wherein R1, R2, R3 and R4 are as described herein. These compounds and pharmaceutical compositions containing the compounds are useful in trea
- -
-
Page/Page column 48
(2010/11/25)
-