55084-66-7Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AND USES THEREOF
-
, (2020/10/21)
Heterocyclic compounds as Weel inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
Investigation of biaryl heterocycles as inhibitors of Wee1 kinase
Mastracchio, Anthony,Lai, Chunqiu,Torrent, Maricel,Bromberg, Kenneth,Buchanan, Fritz G.,Ferguson, Debra,Bontcheva, Velitchka,Johnson, Eric F.,Lasko, Loren,Maag, David,Soni, Nirupama,Shoemaker, Alexander R.,Penning, Thomas D.
, p. 1481 - 1486 (2019/04/25)
In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure?activ
HETEROCYCLIC COMPOUNDS AND USES THEREOF
-
, (2019/04/25)
Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
Pyrimido-diazepines derivative and medical application thereof
-
Paragraph 0026-0027, (2017/11/18)
The invention relates to a pyrimido-diazepines derivative as shown in formula (I) and pharmaceutically acceptable salt, prodrugs and pharmaceutical compositions. The pyrimido-diazepines derivative is a benzodiazepines receptor antagonist. In the formula, R is methyl, ethyl, trifluoromethyl, cyclopropyl, isopropyl and benzyl, and X is hydrogen or chlorine. The invention also discloses preparation of the pyrimido-diazepines derivative and application of the pyrimido-diazepines derivative as drugs. The formula (I) is as shown in the description.
HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
-
Paragraph 00618, (2015/05/06)
The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
Substituted Tricyclic Pyrazolo-Pyrimidine Compounds
-
, (2014/09/29)
The present invention relates to substituted tricyclic pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tricyclic pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
-
Page/Page column 48, (2010/11/25)
This invention is directed to compound of the following formula (I): wherein R1, R2, R3 and R4 are as described herein. These compounds and pharmaceutical compositions containing the compounds are useful in trea
