55290-63-6

Basic information

• Product Name: Atractylodin
• Synonyms: ATRACTYLODIN;(e,e)-2-(1,7-nonadiene-3,5-diynyl)furan;Atractydin;Atisine chloride Atractydin;Furan,2-(1E,7E)-1,7-nonadiene-3,5-diyn-1-yl-;(1E,7E)-1-(2-Furyl)-1,7-nonadiene-3,5-diyne;2-[(1E,7E)-1,7-Nonadiene-3,5-diynyl]furan;Furan, 2-(1,7-nonadiene-3,5-diynyl)-, (E,E)-
• CAS NO: 55290-63-6
• Molecular Formula: C13H10O
• Molecular Weight: 182.22
• Product Categories: Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 55290-63-6.mol

Chemical Properties

• Melting Point: 52 °C
• Boiling Point: 305.5 °C at 760 mmHg
• Flash Point: 142.6 °C
• Appearance: /
• Density: 1.056 g/cm³
• Vapor Pressure: 0.00148mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Atractylodin(CAS DataBase Reference)
• NIST Chemistry Reference: Atractylodin(55290-63-6)
• EPA Substance Registry System: Atractylodin(55290-63-6)

Safety Data

• Hazardous Substances Data: 55290-63-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Atractylodin is used as a therapeutic agent for its hepatoprotective effects, aiding in the protection and regeneration of liver cells. It is particularly useful in treating liver diseases and conditions caused by toxins or viral infections.
Atractylodin is also used as a hypoglycemic agent, helping to lower blood sugar levels and providing relief for individuals with diabetes.
Furthermore, Atractylodin serves as an anti-inflammatory agent, reducing inflammation and alleviating pain associated with various conditions.
In the realm of oncology, Atractylodin is used as an anti-tumor agent, exhibiting potential in inhibiting tumor growth and progression.
Additionally, Atractylodin possesses antibacterial and antiviral properties, making it a useful component in the development of treatments for bacterial and viral infections.
Used in Research and Development:
Atractylodin is utilized in content determination, identification, and pharmacological experiments due to its distinctive chemical properties and diverse range of biological activities. This makes it a valuable tool for scientists and researchers in the field of drug discovery and development.

Pharmacology

Atractylodes is a substance extracted from the dried rhizomes of Atractylodes japonica or Atractylodes japonica. Volatile oil is the main active ingredient in Atractylodes Rhizoma, among which the highest content is Atractylodes Rhizoma, which has pharmacological activities such as lowering blood sugar, diuresis, promoting gastric emptying, anti-inflammatory and anti-tumor.

InChI:InChI=1/C13H10O/c1-2-3-4-5-6-7-8-10-13-11-9-12-14-13/h2-3,8-12H,1H3/b3-2+,10-8+

Upstream product

• 605668-57-3 1-(2-furyl)octa-1,6-dien-4-yn-3-one 
• 605668-56-2 1-(2-furyl)octa-1,6-dien-4-yn-3-ol 
• 77295-71-7 (E)-1,1-Dibromo-trans-1,3-pentadiene 
• 81959-36-6 2-(2-bromovinyl)furan 
• 811861-64-0 (5E)-1-trimethylsilyl-hept-5-ene-1,3-diyne 
• 605668-58-4 2-(3-dibromomethyleneocta-1,6-dien-4-ynyl)furan 

Downstream Products

• 61642-89-5 1-(2-furyl)-(1E,7Z)-nonadiene-3,5-diyne-9-ol 
• 61642-89-5 (2E,8E)-9-(furan-2-yl)nona-2,8-diene-4,6-diyn-1-ol 

Relevant articles and documents

METHOD FOR PRODUCING ATRACTYLODIN AND COBALT COMPLEX COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing atractylodin using a cobalt complex compound of atractylodin where the storage of atractylodin having an unstable chemical structure is made possible for a long period, and the cobalt complex compound. SOLUTION: Provided is a cobalt complex compound represented by formula (I). Also provided is a method for producing atractylodin provided with a step where the cobalt complex compound and a deprotection agent are reacted (A respectively independently denotes CO, P(RA)3 or NO; RA denotes a 1 to 4C straight chain or branched chain alkyl group, phenyl group, aldehyde group, carboxyl group or ester group substituted or unsubstituted with a hydroxyl group, an aldehyde group, a carboxyl group or an ester group; in the case the RA is 2 or more, respectively, independent;and R1 denotes H, a methyl group, a hydroxymethyl group, an aldehyde group or a carboxyl group). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne

A straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A and C, possessing cytotoxic activity against several human solid tumor cells, the atractylodin, with antibiotic activity against Escherichia coli, and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne.

Synthesis of naturally occurring acetylenes via an alkylidene carbenoid rearrangement

Naturally occurring mosquito larvicidal acetylenes 1 and 2, and analogues 3 and 4, each containing either a 1,3-butadiynyl or a 1,3,5-hexatriynyl moiety, are synthesized via a Fritsch - Buttenberg - Wiechell rearrangement. The alkylidene carbenoid interme