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CAS

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55297-95-5

Tiamulin is a semi-synthetic analogue of pleuromutilin, a carbotricyclic compound with an ionisable group for salt formation and greater water solubility. It is a potent and highly selective antibiotic with a unique mode of action, inhibiting protein synthesis by binding to domain V of 23S rRNA.

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  • 55297-95-5 Structure

  • Basic information

    1. Product Name: Tiamulin
    2. Synonyms: TIAMILIN;(3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one;[[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,10R,9aβ)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester;[[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester;[2-(Diethylamino)ethylthio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester;C12065;Tiamulin (100 mg);TiaMulin fuMerate API
    3. CAS NO:55297-95-5
    4. Molecular Formula: C28H47NO4S
    5. Molecular Weight: 493.74
    6. EINECS: 259-580-0
    7. Product Categories: NULL
    8. Mol File: 55297-95-5.mol

  • Chemical Properties

    1. Melting Point: 147.5°C
    2. Boiling Point: 563 °C at 760 mmHg
    3. Flash Point: 294.3 °C
    4. Appearance: /
    5. Density: 1.0160 (rough estimate)
    6. Vapor Pressure: 5.06E-15mmHg at 25°C
    7. Refractive Index: 1.6550 (estimate)
    8. Storage Temp.: -20°C Freezer
    9. Solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
    10. PKA: 14.65±0.70(Predicted)
    11. CAS DataBase Reference: Tiamulin(CAS DataBase Reference)
    12. NIST Chemistry Reference: Tiamulin(55297-95-5)
    13. EPA Substance Registry System: Tiamulin(55297-95-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 2
    5. RTECS: AG9552000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 55297-95-5(Hazardous Substances Data)

55297-95-5 Usage

Uses

Used in Veterinary Medicine:
Tiamulin is used as an antibacterial agent for the treatment of swine dysentery caused by Serpulina hyodysenteriae. It is generally administered as its hydrogen fumarate salt and is effective against a range of Gram-positive bacteria without cross-resistance to existing antibiotic classes.

Safety Profile

Poison by intramuscular and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.

Veterinary Drugs and Treatments

Tiamulin is approved for use in swine to treat pneumonia caused by susceptible strains of Haemophilus pleuropneumoniae and swine dysentery caused by Treponema hyodysenteriae. As a feed additive, it is used to cause increased weight gain in swine.

Check Digit Verification of cas no

The CAS Registry Mumber 55297-95-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,9 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 55297-95:
(7*5)+(6*5)+(5*2)+(4*9)+(3*7)+(2*9)+(1*5)=155
155 % 10 = 5
So 55297-95-5 is a valid CAS Registry Number.
InChI:InChI=1/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19?,20-,22+,24-,25-,26+,27-,28-/m0/s1

55297-95-5 Well-known Company Product Price

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  • USP

  • (1667355)  Tiamulin  United States Pharmacopeia (USP) Reference Standard

  • 55297-95-5

  • 1667355-100MG

  • 4,647.24CNY

  • Detail

55297-95-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name tiamulin

1.2 Other means of identification

Product number -
Other names TiaMulin fuMerate API

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55297-95-5 SDS

55297-95-5Relevant articles and documents

Process for making pleuromutilins

-

, (2008/06/13)

Novel process for the production of antibacterially active pleuromutilin derivatives.

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