- Synthesis of β-damascone from 2,6-dimethylcyclohexanone
-
The synthesis of β-damascone can be achieved from 2,6-dimethylcyclohexanone using a Rupe rearrangement or a Barton vinyl iodation as the key steps.
- Chaumont-Olive, Pauline,Plevová, Kristína,Collado Pérez, Ana María,Sánchez-Quesada, Jorge,?ebesta, Radovan,Cossy, Janine
-
supporting information
p. 140 - 150
(2022/02/10)
-
- One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
-
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mechanical properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the "PEG dilemma", and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodology and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5 °C and demonstrated higher transfection efficiency than positive control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.
- Atochina-Vasserman, Elena N.,Billingsley, Margaret M.,Huang, Ning,Kim, Kyunghee,Liu, Matthew,Maurya, Devendra S.,Mitchell, Michael J.,Ni, Houping,Ona, Nathan,Percec, Virgil,Pochan, Darrin J.,Shahnawaz, Hamna,Weissman, Drew,Xiao, Qi,Zhang, Dapeng
-
supporting information
p. 12315 - 12327
(2021/08/20)
-
- INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE
-
Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
- -
-
Paragraph 00228
(2021/10/02)
-
- TRICYCLIC CRBN LIGANDS AND USES THEREOF
-
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
- -
-
Paragraph 0696; 0710; 0711
(2020/01/24)
-
- Design of nanosystems for the delivery of quorum sensing inhibitors: A preliminary study
-
Biofilm production is regulated by the Quorum Sensing system. Nowadays, Quorum Sensing represents an appealing target to design new compounds to increase antibiotics effects and avoid development of antibiotics multiresistance. In this research the use of liposomes to target two novel synthetic biofilm inhibitors is presented, focusing on a preformulation study to select a liposome composition for in vitro test. Five different liposome (LP) formulations, composed of phosphatidyl choline, cholesterol and charged surfactant (2:1:1, molar ratio) have been prepared by direct hydration and extrusion. As charged surfactants dicetyl phosphate didecyldimethylammonium chloride, di isobutyl phenoxy ethyl dimethyl benzyl ammonium chloride and stearylamine (SA) and have been used. Liposome charge, size and morphology were investigated by zeta potential, photon correlation spectroscopy, small angle x-ray spectroscopy and electron microscopy. LP-SA was selected for the loading of biofilm inhibitors and subjected to high performance liquid chromatography for entrapment capacity evaluation. LP-SA loaded inhibitors showed a higher diameter (223.6 nm) as compared to unloaded ones (205.7 nm) and a dose-dependent anti-biofilm effect mainly after 48 h of treatment, while free biofilm inhibitors loose activity. In conclusion, our data supported the use of liposomes as a strategy to enhance biofilm inhibitors effect.
- Bortolotti, Daria,Cortesi, Rita,Esposito, Elisabetta,Hallan, Supandeep Singh,Marchetti, Paolo,Mariani, Paolo,Rizzo, Roberta,Sguizzato, Maddalena,Trapella, Claudio
-
-
- Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
-
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
- -
-
Page/Page column 149; 151
(2019/11/11)
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- IRAK DEGRADERS AND USES THEREOF
-
The present invention provides compounds, compositions thereof, and methods of using the same.
- -
-
Paragraph 2026; 2027
(2019/07/10)
-
- Benzoate Surfactants for Enhancing the Activity of Lipoprotein Lipase from Burkholderia Species in Organic Solvent
-
Two benzoate surfactants were synthesized and examined as the additives for enhancing the activity of a lipoprotein lipase from Burkholderia species (BSLPL) in organic solvent. It was found that the benzoate surfactants enhanced the turnover number (kcat) by four orders of magnitude and the catalytic efficiency (kcat/Km) by three orders of magnitude. These results strongly suggest that the favorable interaction between the aromatic rings of surfactant tails and the hydrophobic residues around the active site of enzyme may help BSLPL maintain highly active open conformation in organic solvent.
- Oh, Yeonock
-
p. 1093 - 1097
(2019/11/05)
-
- TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE
-
The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.
- -
-
Paragraph 1364
(2018/05/24)
-
- Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition
-
Brequinar, a potent dihydroorotate dehydrogenase (DHODH) inhibitor, has been evaluated in multiple clinical trials as a potential treatment for cancer. To further understand brequinar-based DHODH inhibition and DHODH′s therapeutic relevance in cancer, we
- Madak, Joseph T.,Cuthbertson, Christine R.,Chen, Wenmin,Showalter, Hollis D.,Neamati, Nouri
-
supporting information
p. 13875 - 13878
(2017/09/18)
-
- 8034
-
Abstract A series of arabinose glycosyl sulfamides with varying alkyl chain types and lengths were synthesised as mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Unprecedented conversion of
- Suthagar, Kajitha,Watson, Andrew J.A.,Wilkinson, Brendan L.,Fairbanks, Antony J.
-
p. 153 - 166
(2015/08/24)
-
- Creating protein-imprinted self-assembled monolayers with multiple binding sites and biocompatible imprinted cavities
-
Imprinted monolayers have several advantages over bulk imprinted polymers such as excellent mass transfer of molecules into and out of imprinted sites and transduction of binding signals detected in real time. Protein-imprinted self-assembled monolayers (SAMs) were created with multiple binding sites and biocompatible imprinted cavities from functional thiols and novel disulfide compounds containing an oligoethylene glycol (OEG) terminal moiety and two amide groups incorporated in the chain (DHAP) in a biologically benign solution. DHAP played an important role in the formation of multiple binding sites and biocompatible cavities in addition to resisting nonspecific protein binding. The created protein-imprinted SAMs exhibited the excellent ability of specific binding of target proteins determined by multiple binding sites and imprinted cavities. The strategy generates tailor-made monolayer surfaces with specific protein binding and opens the possibility of controlled assembly of intellectual biomaterials and preparation of biosensors.
- Zhang, Xianfeng,Du, Xuezhong,Huang, Xuan,Lv, Zhongpeng
-
supporting information
p. 9248 - 9251
(2013/07/25)
-
- DENDRIMERS AND METHODS OF PREPARING SAME THROUGH PROPORTIONATE BRANCHING
-
The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from t
- -
-
Paragraph 0092; 0095
(2013/08/14)
-
- Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions
-
Ternary core/shell CdSeS/ZnS-QDs coated with N-acetyl lactosamine was prepared as a fluorescent probe to study the interactions of N-acetyl lactosamine and galectin-3. The synthesis of N-acetyl lactosamine was achieved through the 'azidoiodoglycosylation'
- Yang, Yang,Xue, Xiao-Chao,Jin, Xiao-Feng,Wang, Li-Jun,Sha, Yin-Lin,Li, Zhong-Jun
-
experimental part
p. 7148 - 7154
(2012/09/07)
-
- Avoiding steric congestion in dendrimer growth through proportionate branching: A twist on da Vincis rule of tree branching
-
Making defect-free macromolecules is a challenging issue in chemical synthesis. This challenge is especially pronounced in dendrimer synthesis where exponential growth quickly leads to steric congestion. To overcome this difficulty, proportionate branchin
- Yue, Xuyi,Taraban, Marc B.,Hyland, Laura L.,Yu, Yihua Bruce
-
p. 8879 - 8887
(2013/01/15)
-
- Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals - Radiosynthesis and ex vivo biodistribution of [ 18F]3-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethylthio)-1,2, 5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyrid
-
Muscarinic receptors have been implicated in neurological disorders including Alzheimer's disease, Parkinson's disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities towa
- Van Oosten, Erik M.,Wilson, Alan A.,Mamo, David C.,Pollock, Bruce G.,Mulsant, Benoit H.,Houle, Sylvain,Vasdev, Neil
-
experimental part
p. 1222 - 1232
(2011/02/24)
-
- Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1
-
Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro. The Royal Society of Chemistry 2009.
- Foley, David,Bailey, Patrick,Pieri, Myrtani,Meredith, David
-
supporting information; scheme or table
p. 1064 - 1067
(2009/05/30)
-
- The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1
-
A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.
- Foley, David,Pieri, Myrtani,Pettecrew, Rachel,Price, Richard,Miles, Stephen,Lam, Ho Kam,Bailey, Patrick,Meredith, David
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supporting information; experimental part
p. 3652 - 3656
(2009/10/23)
-
- High-purity discrete PEG-oligomer crystals allow structural insight
-
To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 310-helical PEG structures.
- French, Alister C.,Thompson, Amber L.,Davis, Benjamin G.
-
supporting information; experimental part
p. 1248 - 1252
(2009/06/30)
-
- Synthesis of bifunctional integrin-binding peptides containing PEG spacers of defined length for non-viral gene delivery
-
Improving the buffer and serum stability of non-viral gene delivery vectors, and increasing their circulation time in vivo, is an important focus of current research in gene therapy. The most successful strategies to date have involved shielding the complexes with large polydisperse PEG adducts. However, this approach is accompanied by a fall in transfection efficiency. In this paper we describe the solid-phase synthesis of a series of bifunctional peptides bearing short PEG spacers of defined structure as components of lipopolyplex gene delivery vectors. Short, high-yielding routes to a series of PEG-amino acids are described: these PEG-amino acids can be used in varying combinations to afford bifunctional peptides with varying lengths of PEG spacers by using standard solid-phase synthesis techniques. A series of lipopolyplexes were formulated using these bifunctional peptides, and their transfection properties assessed. Dynamic light scattering measurements on the complex with the best transfection properties showed that in phosphate-buffered saline this complex was considerably more stable, and aggregated more slowly, than a complex formulated using a similar peptide lacking the short PEG spacer. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
- Pilkington-Miksa, Michael A.,Sarkar, Supti,Writer, Michele J.,Barker, Susie E.,Shamlou, Parviz Ayazi,Hart, Stephen L.,Hailes, Helen C.,Tabor, Alethea B.
-
experimental part
p. 2900 - 2914
(2009/04/11)
-
- Bna Conjugates and Methods of Use
-
Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, decreasing arterial blood pressure and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, enteral, subcutaneous, pulmonary, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the hBNP compound are also disclosed, having an amino acid sequence that is other than the native sequence.
- -
-
Page/Page column 31
(2008/12/08)
-
- Ionic strength mediated hydrophobic force switching of CF 3-terminated ethylene glycol self-assembled monolayers (SAMs) on gold
-
We have synthesised novel oligo(ethylene glycol), CF3-terminated switching self-assembled monolayers, which allow the force experienced by a hydrophobic object to be controlled via the ionic strength of the environment. The Royal Society of Chemistry.
- Bonnet, Nelly,O'Hagan, David,Haehner, Georg
-
p. 5066 - 5068
(2008/09/18)
-
- Synthesis of oligo(ethylene glycol) toward 44-mer
-
A synthetic method for oligo(ethylene glycol) toward 44-mer (FW = 1956.35) is described. Reiteration of Williamson's ether synthesis and hydrogenation to remove protecting benzyl group affords desired oligo(ethylene glycol) toward 44-mer in moderate yields. The advantages in this method are use of commercially easily available materials as starting materials and procedures avoiding difficulty in purification of the products as much as possible.
- Ahmed, Saleh A.,Tanaka, Mutsuo
-
p. 9884 - 9886
(2007/10/03)
-
- Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains
-
A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2-CH2)nY (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.
- Loiseau, Francois A.,Hii, King Kuok,Hill, Alison M.
-
p. 639 - 647
(2007/10/03)
-
- Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (-)-stipiamide
-
A series of five homodimeric polyethylene glycol (PEG) linked homodimers based on the multidrug resistance reversal agent (-)-stipiamide were made and tested for their ability to interact with P-glycoprotein, the protein responsible for multidrug resistance, using ATPase and photoaffinity displacement assays. Key reactions include a new alkoxide-mesylate displacement for the assembly of the PEG linkers and a double Sonogashira coupling reaction.
- Andrus, Merritt B.,Turner, Timothy M.,Updegraff, Emily P.,Sauna, Zuben E.,Ambudkar, Suresh V.
-
p. 3819 - 3822
(2007/10/03)
-
- Highly selective Silver(I) oxide mediated monoprotection of symmetrical diols
-
Treatment of symmetrical diol with Ag2O and alkyl halide gave the monoprotected derivative in good to excellent yield.
- Bouzide, Abderrahim,Sauve, Gilles
-
p. 5945 - 5948
(2007/10/03)
-
- Ethoxylation of aralkyl alcohols
-
An important reaction, the oligoaddition of ethylene oxide to the alcoholic hydroxyl group was investigated.The aralkyl alcohols were chosen as base material: benzyl-, β-phenylethyl- and γ-phenylpropyl alcohols.The first members of their homologue ethoxylated series were prepared and used as standards for the determination of the average degree of ethoxylation (IR, UV, refractive indices) and of the molar mass distribution (HPLC).
- Huszar, Klara Parlagh,Klug, Otto,Parlagh, Gyula,Rusznak, Istvan,Sallay, Peter,et al.
-
p. 241 - 252
(2007/10/03)
-
- A novel way for hydroxyethylation by using clay catalysts
-
Hydroxyethylation of aralkyl alcohols (benzyl alcohol, 2-phenylethanol, 3-phenylpropanol) in the presence of a clay catalyst (K10) was successful. This method has some advantages in contrast with the conventional ones: effective, works at mild reaction conditions, ease the separation of catalyst from the reaction mixture.
- Sallay, Peter,Bekassy, Sandor,Ahmed, Mohamed H.,Farkas, Laszlo,Rusznak, Istvan
-
p. 661 - 664
(2007/10/03)
-
- Homogeneous hydroxyethylation of phenyl-substituted alcohols
-
Homogeneous glycol ether derivatives of phenyl group substituted alcohols (benzyl-, β-phenyl ethyl- and γ-phenyl propyl-) were synthesised by repeated Williamson synthesis starting in two cases from the halogen derivatives of the corresponding alcohols. In the case of β-phenylethanol the first homologue was prepared in the reaction of benzyl group protected ethylene chlorohydrine and β-phenyl-ethyl alcohol. The reaction product was hydrogenolysed (removing the benzyl group by hydrogenolyzis), halogenated and used to the synthesis of higher homologues as starting material.
- Sallay, Peter,Ahmed, Mohamed H. M.,Rusznak, Istvan,Farkas, Laszlo,Tungler, Antal
-
-
- Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode
-
To develop an ionophore that is highly selective for sodium for use in an ion-selective electrode, we propose a model based on 16-crown-5 which has a cavity just the size of Na+ and has a "block" subunit to prevent complex formation with ions l
- Suzuki, Koji,Sato, Kazunari,Hisamoto, Hideaki,Siswanta, Dwi,Hayashi, Kazuo,Kasahara, Noriko,Watanabe, Kazuhiko,Yamamoto, Noriko,Sasakura, Hideshi
-
p. 208 - 215
(2007/10/03)
-
- Lack of effect of the length of oligoglycine- and oligo(ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in solution
-
Using 1H NMR spectroscopy, values of T2 have been determined for the methylene protons of the oligoglycine moieties of para-substituted benzenesulfonamides having structures H2NO2SC6H4CO(Gly)(n)OH (n = 1-6) bound at the active site of bovine carbonic anhydrase II (CA, EC 4.2.1.1). These values have been correlated with measurements of dissociation constants of these complexes, in order to infer motion of these ligands when bound to the enzyme. Motion of glycines 1-3 (those closest to the aryl ring) is hindered by their proximity to the protein; motion of glycines 4-6 is relatively unhindered. Despite the restriction to motion inferred for glycines 1-3, the values of K(d) for the six compounds (n = 1-6, 1-6) are indistinguishable within experimental uncertainty (± 20%): K(d) in μM (n) 0.30 (1); 0.26 (2); 0.33 (3); 0.37 (4); 0.37 (5); 0.34 (6). There is, therefore, an unexpected compensation of the loss in conformational entropy on binding by another contributor to the free energy.
- Jain, Ahamindra,Huang, Shaw G.,Whitesides, George M.
-
p. 5057 - 5062
(2007/10/02)
-
- Analysis of the Conformational Behaviour of Perfunctionalized β-Cyclodextrins. Part 1. Evidence for Insertion of one of the Rim Substituents into the Cyclodextrin Cavity in Organic Solvents
-
Several functionalized β-cyclodextrins have been shown to exhibit conformational isomerism.The analysis of the conformational behaviour of several derivatives strongly suggests that a slow exchange occurs between C7 and C1 conformers, the C1 probably invo
- Jullien, Ludovic,Canceill, Josette,Lacombe, Liliane,Lehn, Jean-Marie
-
p. 989 - 1002
(2007/10/02)
-
- Synthesis, Characterization, and Alkali Metal Stability Constants of a New Bis(phosphotriester) Macrobicyclic Polyether Cryptand
-
The synthesis of a new bis(phosphotriester) macrobicyclic polyether cryptand, O=P3P=O (9), called phosphocrypt, and its acyclic tripodal precursor O=P3 (8) are described.The new cryptand 9 was synthesized by condensation of 8 and phosphoryl chloride which were simultaneously added under high dilution conditions in the presence of pyridine.The highest yield of 9 (30percent) was obtained with a final concentration of 3 mM in vigorously stirred methylene chloride.Both 8 and 9 form stable complexes with K(1+) and Rb(1+) in water.Log Ks values measured with a cation selective electrode for 8 are 3.6 and 3.0 and 3.7 and 3.6 for 9, respectively.The Ks values for phosphocrypt are 1000-fold greater than those of comparably sized nitrogen bridgehead cryptands. 1H and 13C NMR indicate 9 is flexible at 20 deg C.Molecular dynamics and mechanics calculations indicate that phosphocrypt has more cation-dipole interactions and more favorable conformational changes associated with complexation than comparably sized nitrogen bridgehead cryptands.
- Allan, Christian B.,Spreer, Larry O.
-
p. 7695 - 7700
(2007/10/02)
-
- Synthesis of ω-(methoxycarbonyl)alkyl and 9-(methoxycarbonyl)-3,6-dioxanonyl glycopyranosides for the preparation of carbohydrate-protein conjugates
-
ω-(Methoxycarbonyl)alkyl glycopyranosides of D-mannose having C4, C7, C9, C12, and C15 carbon chains, L-fucose and 2-acetamido-2-deoxy-D-mannose having C7 and C9 carbon chains, D
- Sugawara,Irie,Iwasawa,Yoshikawa,Okuno,Watanabe,Kato,Shibukawa,Ito
-
p. 117 - 149
(2007/10/02)
-
- Competitive solvent extraction of alkali metal cations into chloroform by lipophilic acyclic proton-ionizable polyethers
-
A series of lipophilic acyclic polyether carboxylic acids and a corresponding polyether phosphonic acid monoethyl ester were synthesized in which the unit that contains the lipophilic and the proton-ionizable groups is held constant, but the polyether chain and its terminal group are systematically varied. Competitive solvent extraction of alkali metal cations from aqueous solutions into chloroform was performed to assess the influence of structural variation within the extractant molecule upon the extraction selectivity and efficiency. Many of the ionophores exhibited extraction selectivity for Li+. One of the simplest chelating agents gave an extraction selectivity order of Li+ ? Na+ > K+,Rb+ > Cs+ and a Li+/Na+ selectivity ratio of 4.9, while the selectivity ratios for Li+ over K+, Rb+, and Cs+ were 12 or higher.
- Walkowiak, Wladyslaw,Ndip, Grace M.,Desai, Dhimant H.,Lee, Han Koo,Bartsch, Richard A.
-
p. 1685 - 1690
(2007/10/02)
-
- Transannular Interaction of Functional Groups in Tetracyclo4,11.05,9>undec-6-en-2-one. - Unexpected Course of a Ketalization Reaction
-
The reaction of polycyclic enones 1 with ethylene glycol yielded beside the ketal 2 as main product unexpectedly the cyclic polyether 3.The structure of 3 was established by spectroscopic analysis and independent synthesis starting from 10a and 12a.The analogous synthesis of polyether 17 is described. Key Words: Transannular interaction / Cyclic polyethers / Ruthenium tetroxide catalyzed oxidation
- Ipaktschi, Junes,Sang, Bernd
-
p. 1029 - 1032
(2007/10/02)
-
- A Novel Procedure for the Synthesis of Ether-Bridged Perfluoro Non-Ionic Surfactants
-
An efficient procedure is described for the synthesis of perfluoro non-ionic surfactants of the type RF-CH2(OC2H4)pOH which involves the use of the principle of solid-liquid phase transfer methodology to simplify the Williamson ether synthesis usually employed in previous procedures.
- Selve, C.,Achilefu, S.,Mansuy, L.
-
p. 799 - 807
(2007/10/02)
-
- Synthesis of Monodisperse Perfluoroalkyl-Oxyethylene Surfactants with Methoxy Capping: Surfactants of High Chemical Inertness
-
Monodisperse fluoroalkyl non-ionic surfactants with a methoxy group capping the hydrophilic head, and having a high chemical inertness and surface properties typical of perfluorinated non-ionic surfactants, have been synthesized.
- Selve, Claude,Achilefu, Samuel
-
p. 911 - 912
(2007/10/02)
-
- A NOVEL, UNEQUIVOCAL SYNTHESIS OF POLYETHYLENE GLYCOLS
-
Unequivocal synthesis of polyethyleneglycols is presented.The key step for this synthesis is the selective monobenzylation of oligoethyleneglycols by the phase transfer catalysis technique.
- Coudert, Gerard,Mpassi, Michel,Guillaumet, Gerald,Selve, Claude
-
-
- On the surface-anesthetic activity of some ether alcohols (author's transl)
-
An account of the preparation and surface anesthetic potency of 12 ether alcohols of the type X-O-Y-OH is given in this paper. The anaesthetic intensity and effective duration of a chloronaphthalene derivative of this type lie within the range of action of cocain.
- Riemschneider,Rufer,Chik
-
p. 2061 - 2063
(2007/10/05)
-
- Topical mosquito repellents VII: Alkyl triethylene glycol monoethers
-
Normal and branched chain aliphatic monoethers of triethylene glycol are effective topical mosquito repellents. In terms of duration of protection, they are generally superior to the corresponding diethylene glycol analogs, and some are superior to diethyltoluamide. The n heptyl monoether of triethylene glycol affords double the protection time of diethyltoluamide under controlled laboratory conditions, and appears to be a useful new mosquito repellent.
- Johnson,DeGraw,Engstrom,Skinner,Brown,Skidmore,Maibach
-
p. 693 - 695
(2007/10/05)
-