55489-58-2Relevant articles and documents
Synthesis of β-damascone from 2,6-dimethylcyclohexanone
Chaumont-Olive, Pauline,Plevová, Kristína,Collado Pérez, Ana María,Sánchez-Quesada, Jorge,?ebesta, Radovan,Cossy, Janine
supporting information, p. 140 - 150 (2022/02/10)
The synthesis of β-damascone can be achieved from 2,6-dimethylcyclohexanone using a Rupe rearrangement or a Barton vinyl iodation as the key steps.
INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE
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Paragraph 00228, (2021/10/02)
Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
Design of nanosystems for the delivery of quorum sensing inhibitors: A preliminary study
Bortolotti, Daria,Cortesi, Rita,Esposito, Elisabetta,Hallan, Supandeep Singh,Marchetti, Paolo,Mariani, Paolo,Rizzo, Roberta,Sguizzato, Maddalena,Trapella, Claudio
, (2021/06/14)
Biofilm production is regulated by the Quorum Sensing system. Nowadays, Quorum Sensing represents an appealing target to design new compounds to increase antibiotics effects and avoid development of antibiotics multiresistance. In this research the use of liposomes to target two novel synthetic biofilm inhibitors is presented, focusing on a preformulation study to select a liposome composition for in vitro test. Five different liposome (LP) formulations, composed of phosphatidyl choline, cholesterol and charged surfactant (2:1:1, molar ratio) have been prepared by direct hydration and extrusion. As charged surfactants dicetyl phosphate didecyldimethylammonium chloride, di isobutyl phenoxy ethyl dimethyl benzyl ammonium chloride and stearylamine (SA) and have been used. Liposome charge, size and morphology were investigated by zeta potential, photon correlation spectroscopy, small angle x-ray spectroscopy and electron microscopy. LP-SA was selected for the loading of biofilm inhibitors and subjected to high performance liquid chromatography for entrapment capacity evaluation. LP-SA loaded inhibitors showed a higher diameter (223.6 nm) as compared to unloaded ones (205.7 nm) and a dose-dependent anti-biofilm effect mainly after 48 h of treatment, while free biofilm inhibitors loose activity. In conclusion, our data supported the use of liposomes as a strategy to enhance biofilm inhibitors effect.