- INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR
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The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.
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Paragraph 0113-0114
(2019/06/07)
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- Indole derivative serving as CRTH2 inhibitor
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The invention discloses an indole derivative serving as a CRTH2 inhibitor shown as a formula (I) as shown in the specification or pharmaceutically acceptable salts, as well as application of the indole derivative in treatment of diseases related to the CR
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Paragraph 0151; 0152; 0153
(2018/05/16)
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- SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS
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The present invention relates to compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
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Page/Page column 48
(2008/12/08)
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- Palladium catalysed Suzuki reactions of fluoroarenes
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A novel palladium catalysed cleavage of C-F bonds in a series of Suzuki reactions of aryl fluorides is described together with a discussion of the mechanistic implications.
- Widdowson, David A.,Wilhelm, Rene
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p. 578 - 579
(2007/10/03)
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