- Synthesis of [2H4]oxymetazoline and [ 14C]oxymetazoline
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An efficient synthesis of [2H4] and [ 14C]oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [2H4]oxymetazoline from [2H4]ethylene diamine was achieved in one step with a 40% yield. The synthesis of [14C]oxymetazoline from potassium [ 14C]cyanide was achieved in two steps with an overall radiochemical yield of 67%. Copyright
- Brugger, Michelle L.,Borges, Scott,Ren, Sumei,McNamara, Paul
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experimental part
p. 793 - 795
(2012/03/08)
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- Synthesis of 3-Hydroxy-2,6-dimethyl-1-phenyl- and 3,4-Dihydroxy-2,6-dimethyl-1-phenyl-acetic Acids, Two Potential Synthons
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4-t-Butyl-3-hydroxy-2,6-dimethyl-1-benzylchloride (VIII), obtained from 2,4-dimethylphenol (VI), is converted into the cyanomethylphenols (IX) or (X) depending on the experimental conditions and both give the phenylacetic acid (I).Compound I in turn affords the dihydroxyphenylacetic acid (XII), via the 1,2-benzoquinone (XIII), by iodoxybenzene oxidation, reductive acetylation and hydrolysis.
- Raju, B.,Rao, G. S. Krishna
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p. 469 - 470
(2007/10/02)
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- 2,4,6-Trialkyl L-3-hydroxyphenylalkanoates
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Ester and amides having the formula SPC1 Wherein R, R1 and R2 are independently lower alkyl or cycloalkyl groups, R3 is hydrogen, alkyl, cycloalkyl, alkylene, phenyl, phenyl substituted by alkyl groups, alkylthioethyl, thiobis-alkylene, alkyleneoxyalkylene, polyoxyalkylene or a polyvalent cyclic or acyclic hydrocarbon radical, R4 is hydrogen, lower alkyl, cycloalkyl, R5 is hydrogen, alkyl, phenyl, phenyl substituted by alkyl groups, alkylene, a polyvalent cyclic or acyclic hydrocarbon radical or alkyleneoxyalkylene, A is lower alkylene, m is 1 to 4 and n is 1 to 6. The esters are prepared by usual esterification procedures from a suitable alcohol and an acid of the formula III SPC2 or an acid halide or acid anhydride thereof. The higher alkyl esters can also be prepared from the lower alkyl ester, especially the methyl ester, by transesterification with a higher alkanol or polyol. The amides are prepared by usual amidation procedures by reacting a carboxylic acid of formula III, an acid chloride, anhydride or a lower alkyl ester thereof with the appropriate amine. The nitriles corresponding to acids of formula III are prepared as well as some malonate esters derived having the formula V. SPC3 The compounds are useful as stabilizers or organic materials, especially polyolefins, which deteriorate upon exposure to light and heat.
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