55718-48-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(9H-FLUOREN-3-YL)-ETHANONE is used as a starting material for the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(9H-FLUOREN-3-YL)-ETHANONE serves as a starting material for the synthesis of different agrochemicals, including pesticides and fertilizers, to enhance agricultural productivity and crop protection.
Used in Material Science:
1-(9H-FLUOREN-3-YL)-ETHANONE is used as a building block in the development of new materials and polymers. Its aromatic ketone structure provides a foundation for creating innovative materials with specific properties for various applications.
Used in Organic Chemistry Research:
As an important intermediate in organic chemistry, 1-(9H-FLUOREN-3-YL)-ETHANONE is utilized in research to explore new synthetic pathways, reactions, and the development of novel organic compounds with diverse applications.

InChI:InChI=1/C15H12O/c1-10(16)11-6-7-13-8-12-4-2-3-5-14(12)15(13)9-11/h2-7,9H,8H2,1H3

Upstream product

• 55341-72-5 9H-fluorene-3-carbonyl chloride 
• 506-82-1 dimethylcadmium 
• 1190085-16-5 2-(3-acetylphenyl)benzyl chloride 
• 86-73-7 9H-fluorene 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: Synthesis and antitumor activity

A series of novel (±)-3-substituted fluorene-imidazolium/triazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of 2-methyl-benzimidazole or 5,6-dimethyl-benzimidazole rings and substitution of the imidazolyl/triazolyl-3/4-position with a naphthylacyl or 4-methoxyphenacyl group were important for modulating cytotoxic activity. Compounds 37 and 42 were found to be the most potent derivatives with IC50 values of 0.51-2.51 μM and exhibited cytotoxic activities selectively against myeloid leukaemia (HL-60), liver carcinoma (SMMC-7721) and lung carcinoma (A549). Compound 37 can remarkably induce the G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells. Additionally, compound 30 exhibited selective cytotoxicity to some extent between cancer cells (A549) and normal cells (BEAS-2B).

Method for reducing carbonyl reduction to methylene under illumination

The invention belongs to the technical field of organic chemical synthesis. The method comprises the following steps: (1) mixing the carbonyl compound and the amine compound in a solvent, reacting 3 - 6 under the illumination of 380 - 456 nm, the reaction system is low in toxicity, high in atom utilization rate 12 - 24h. and production efficiency, safe and controllable in reaction process and capable of simplifying the operation in the preparation and production process. At the same time, the residue toxicity of the reaction is minimized, the pollution caused by the production process to the environment is reduced, and the steps and operations of removing residues after the reaction are simplified. In addition, the reactant feedstock is readily available. The reactant does not need additional modification before the reaction, can be directly used for preparing production, simplifies the operation steps, and shortens the reaction route. The production cost is obviously reduced.

Highly efficient and versatile synthesis of polyarylfluorenes via Pd-catalyzed C-H bond activation

A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance