Direct Amidation of Carboxylic Acids with Nitroarenes
N-Aryl amides are an important class of compounds in pharmaceutical and agrochemical chemistry. Rapid and low-cost synthesis of N-aryl amides remains in high demand. Herein, we disclose an operationally simple process to access N-aryl amides directly from readily available nitroarenes and carboxylic acids as coupling substrates. This method involves the in situ activation of carboxylic acids to acyloxyphosphonium salt for one-pot amidation, without the need for isolation of the corresponding synthetic intermediates. Furthermore, the ease of preparation and workup allow the quick and efficient synthesis of a wide range of N-aryl amides, including several amide-based druglike and agrochemical molecules.
Wang, Shao-Peng,Cheung, Chi Wai,Ma, Jun-An
p. 13922 - 13934
(2019/11/03)
Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes
Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.
2-Alkylbenzanilide is produced by reacting an alkyl 2-alkylbenzoate having the formula STR1 wherein X represents a lower alkyl group and R represents a lower alkyl group with an aniline having the formula STR2 wherein Y represents hydrogen atom, an alkoxy
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(2008/06/13)
Compositions and methods of combatting bacteria and fungi using 2-methylbenzanilide derivatives
An agricultural germicide having the formula SPC1 Wherein R represents C1-12 alkyl, alkenyl, alkynyl, benzyl or chlorobenzyl.
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(2008/06/13)
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